Transition from Schizotypal Disorder to Non-Affective Psychotic Disorders Including Schizophrenia: A Nationwide Swedish Cohort Study
Lindström, Sara LU
; Nordgaard, Julie
and Berge, Jonas
LU
(2025)
In Psychiatry Research
- Abstract
- This study evaluated the transition rates from schizotypal disorder to non-affective psychosis and schizophrenia in particular aiming to identify clinical and demographic factors associated with these transitions. We conducted a nationwide cohort study using data from the Swedish Patient Register and the Cause of Death Register, including patients aged 18 and older diagnosed with schizotypal disorder (ICD-10 F21) between 2006 and 2017. Cox proportional hazards regression was employed to assess the associations between baseline characteristics and transitions to schizophrenia (ICD-10 F20) and other non-affective psychotic disorders (ICD-10 F20-F29, excluding F21), with follow-up extending up to 12 years. Of the 667 patients included, 12.0%... (More)
- This study evaluated the transition rates from schizotypal disorder to non-affective psychosis and schizophrenia in particular aiming to identify clinical and demographic factors associated with these transitions. We conducted a nationwide cohort study using data from the Swedish Patient Register and the Cause of Death Register, including patients aged 18 and older diagnosed with schizotypal disorder (ICD-10 F21) between 2006 and 2017. Cox proportional hazards regression was employed to assess the associations between baseline characteristics and transitions to schizophrenia (ICD-10 F20) and other non-affective psychotic disorders (ICD-10 F20-F29, excluding F21), with follow-up extending up to 12 years. Of the 667 patients included, 12.0% transitioned to schizophrenia, and 22.5% to other non-affective psychotic disorders. The estimated 10-year cumulative risks of transition were 24.6% for schizophrenia and 43.5% for non-affective psychotic disorders. Older age and diagnosis allocated during the study's early observation years were associated with a reduced risk of transition to schizophrenia, while pre-existing depression and anxiety disorders had protective effects. In contrast, substance use disorders other than alcohol were associated with an increased risk of transitioning to non-affective psychotic disorders. These findings highlight that a significant portion of individuals with schizotypal disorder progress to more severe psychotic disorders, underlining the need for careful monitoring, especially in those with comorbid substance use. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/82e1e2af-f181-459b-a022-3efca3d1804e
- author
- Lindström, Sara
LU
; Nordgaard, Julie
and Berge, Jonas
LU
- organization
- publishing date
- 2025-03-25
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- Psychiatry Research
- publisher
- Elsevier
- external identifiers
-
- scopus:105001106532
- pmid:40156984
- ISSN
- 1872-7123
- DOI
- 10.1016/j.psychres.2025.116470
- language
- English
- LU publication?
- yes
- id
- 82e1e2af-f181-459b-a022-3efca3d1804e
- date added to LUP
- 2025-03-27 09:45:49
- date last changed
- 2025-06-27 03:00:07
@article{82e1e2af-f181-459b-a022-3efca3d1804e,
abstract = {{This study evaluated the transition rates from schizotypal disorder to non-affective psychosis and schizophrenia in particular aiming to identify clinical and demographic factors associated with these transitions. We conducted a nationwide cohort study using data from the Swedish Patient Register and the Cause of Death Register, including patients aged 18 and older diagnosed with schizotypal disorder (ICD-10 F21) between 2006 and 2017. Cox proportional hazards regression was employed to assess the associations between baseline characteristics and transitions to schizophrenia (ICD-10 F20) and other non-affective psychotic disorders (ICD-10 F20-F29, excluding F21), with follow-up extending up to 12 years. Of the 667 patients included, 12.0% transitioned to schizophrenia, and 22.5% to other non-affective psychotic disorders. The estimated 10-year cumulative risks of transition were 24.6% for schizophrenia and 43.5% for non-affective psychotic disorders. Older age and diagnosis allocated during the study's early observation years were associated with a reduced risk of transition to schizophrenia, while pre-existing depression and anxiety disorders had protective effects. In contrast, substance use disorders other than alcohol were associated with an increased risk of transitioning to non-affective psychotic disorders. These findings highlight that a significant portion of individuals with schizotypal disorder progress to more severe psychotic disorders, underlining the need for careful monitoring, especially in those with comorbid substance use.}},
author = {{Lindström, Sara and Nordgaard, Julie and Berge, Jonas}},
issn = {{1872-7123}},
language = {{eng}},
month = {{03}},
publisher = {{Elsevier}},
series = {{Psychiatry Research}},
title = {{Transition from Schizotypal Disorder to Non-Affective Psychotic Disorders Including Schizophrenia: A Nationwide Swedish Cohort Study}},
url = {{http://dx.doi.org/10.1016/j.psychres.2025.116470}},
doi = {{10.1016/j.psychres.2025.116470}},
year = {{2025}},
}