Complement contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome
(2016) In Kidney International 90(4). p.9-726- Abstract
Complement is activated during Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS). There is evidence of complement activation via the alternative pathway in STEC-HUS patients as well as from in vivo and in vitro models. Ozaki et al. demonstrate activation of the mannose-binding lectin (MBL) pathway in Shiga toxin-treated mice expressing human MBL2, but lacking murine Mbls. Treatment with anti-human MBL2 antibody was protective, suggesting that MBL pathway activation also contributes to Shiga toxin-mediated renal injury.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/846062da-7d99-4f2c-93e5-2ef07fea7bd0
- author
- Karpman, Diana LU and Tati, Ramesh LU
- organization
- publishing date
- 2016-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Journal Article
- in
- Kidney International
- volume
- 90
- issue
- 4
- pages
- 4 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:27633864
- scopus:85015392794
- wos:000384388800004
- ISSN
- 1523-1755
- DOI
- 10.1016/j.kint.2016.07.002
- language
- English
- LU publication?
- yes
- id
- 846062da-7d99-4f2c-93e5-2ef07fea7bd0
- date added to LUP
- 2017-02-08 15:47:44
- date last changed
- 2024-07-07 11:14:42
@misc{846062da-7d99-4f2c-93e5-2ef07fea7bd0, abstract = {{<p>Complement is activated during Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS). There is evidence of complement activation via the alternative pathway in STEC-HUS patients as well as from in vivo and in vitro models. Ozaki et al. demonstrate activation of the mannose-binding lectin (MBL) pathway in Shiga toxin-treated mice expressing human MBL2, but lacking murine Mbls. Treatment with anti-human MBL2 antibody was protective, suggesting that MBL pathway activation also contributes to Shiga toxin-mediated renal injury.</p>}}, author = {{Karpman, Diana and Tati, Ramesh}}, issn = {{1523-1755}}, keywords = {{Journal Article}}, language = {{eng}}, number = {{4}}, pages = {{9--726}}, publisher = {{Nature Publishing Group}}, series = {{Kidney International}}, title = {{Complement contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome}}, url = {{http://dx.doi.org/10.1016/j.kint.2016.07.002}}, doi = {{10.1016/j.kint.2016.07.002}}, volume = {{90}}, year = {{2016}}, }