Filovirus transcription and replication
(2015) p.515-555- Abstract
- Filoviruses belong to the group of nonsegmented, negative-sense (NNS) RNA viruses and are members of the order Mononegavirales along with the rhabdo-, paramyxo-, nyami-, and bornaviruses. Mononegaviruses share a general mechanism to replicate and transcribe their genomes, reflected in functionally homologous proteins and a similar genome structure. Although basic mechanisms are similar between rhabdo- and filoviral RNA synthesis, both virus families have developed distinct features. In this chapter, we describe the concepts underlying filovirus replication and transcription. We introduce the technologies that have enabled scientists to decipher the viral replication cycle and discuss recent insights in the regulation of filoviral RNA... (More)
- Filoviruses belong to the group of nonsegmented, negative-sense (NNS) RNA viruses and are members of the order Mononegavirales along with the rhabdo-, paramyxo-, nyami-, and bornaviruses. Mononegaviruses share a general mechanism to replicate and transcribe their genomes, reflected in functionally homologous proteins and a similar genome structure. Although basic mechanisms are similar between rhabdo- and filoviral RNA synthesis, both virus families have developed distinct features. In this chapter, we describe the concepts underlying filovirus replication and transcription. We introduce the technologies that have enabled scientists to decipher the viral replication cycle and discuss recent insights in the regulation of filoviral RNA synthesis. We also highlight differences in RNA synthesis between filoviruses and two widely studied rhabdoviruses, vesicular stomatitis virus (VSV) of the Vesiculovirus genus and rabies virus (RABV) of the Lyssavirus genus. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8726508
- author
- Brauburger, Kristina LU ; Deflubé, Laure R and Mühlberger, Elke
- publishing date
- 2015
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- Biology and Pathogenesis of Rhabdo-and Filoviruses
- editor
- Pattnaik, A K and Whitt, M A
- pages
- 515 - 555
- publisher
- World Scientific Publishing
- external identifiers
-
- scopus:84988565665
- ISBN
- 978-981-4635-33-2
- 978-981-4635-35-6
- DOI
- 10.1142/9789814635349_0020
- language
- English
- LU publication?
- no
- id
- 457d1689-1bb1-4e18-a9b3-a1f53b475e1d (old id 8726508)
- alternative location
- http://www.worldscientific.com/doi/pdf/10.1142/9789814635349_bmatter
- date added to LUP
- 2016-04-04 11:07:42
- date last changed
- 2022-03-31 17:59:20
@inbook{457d1689-1bb1-4e18-a9b3-a1f53b475e1d, abstract = {{Filoviruses belong to the group of nonsegmented, negative-sense (NNS) RNA viruses and are members of the order Mononegavirales along with the rhabdo-, paramyxo-, nyami-, and bornaviruses. Mononegaviruses share a general mechanism to replicate and transcribe their genomes, reflected in functionally homologous proteins and a similar genome structure. Although basic mechanisms are similar between rhabdo- and filoviral RNA synthesis, both virus families have developed distinct features. In this chapter, we describe the concepts underlying filovirus replication and transcription. We introduce the technologies that have enabled scientists to decipher the viral replication cycle and discuss recent insights in the regulation of filoviral RNA synthesis. We also highlight differences in RNA synthesis between filoviruses and two widely studied rhabdoviruses, vesicular stomatitis virus (VSV) of the Vesiculovirus genus and rabies virus (RABV) of the Lyssavirus genus.}}, author = {{Brauburger, Kristina and Deflubé, Laure R and Mühlberger, Elke}}, booktitle = {{Biology and Pathogenesis of Rhabdo-and Filoviruses}}, editor = {{Pattnaik, A K and Whitt, M A}}, isbn = {{978-981-4635-33-2}}, language = {{eng}}, pages = {{515--555}}, publisher = {{World Scientific Publishing}}, title = {{Filovirus transcription and replication}}, url = {{http://dx.doi.org/10.1142/9789814635349_0020}}, doi = {{10.1142/9789814635349_0020}}, year = {{2015}}, }