Perinatal risk factors for acute myeloid leukemia
(2015) In European Journal of Epidemiology 30(12). p.1277-1285- Abstract
- Infectious etiologies have been hypothesized for acute leukemias because of their high incidence in early childhood, but have seldom been examined for acute myeloid leukemia (AML). We conducted the first large cohort study to examine perinatal factors including season of birth, a proxy for perinatal infectious exposures, and risk of AML in childhood through young adulthood. A national cohort of 3,569,333 persons without Down syndrome who were born in Sweden in 1973-2008 were followed up for AML incidence through 2010 (maximum age 38 years). There were 315 AML cases in 69.7 million person-years of follow-up. We found a sinusoidal pattern in AML risk by season of birth (P < 0.001), with peak risk among persons born in winter. Relative to... (More)
- Infectious etiologies have been hypothesized for acute leukemias because of their high incidence in early childhood, but have seldom been examined for acute myeloid leukemia (AML). We conducted the first large cohort study to examine perinatal factors including season of birth, a proxy for perinatal infectious exposures, and risk of AML in childhood through young adulthood. A national cohort of 3,569,333 persons without Down syndrome who were born in Sweden in 1973-2008 were followed up for AML incidence through 2010 (maximum age 38 years). There were 315 AML cases in 69.7 million person-years of follow-up. We found a sinusoidal pattern in AML risk by season of birth (P < 0.001), with peak risk among persons born in winter. Relative to persons born in summer (June-August), incidence rate ratios for AML were 1.72 (95 % CI 1.25-2.38; P = 0.001) for winter (December-February), 1.37 (95 % CI 0.99-1.90; P = 0.06) for spring (March-May), and 1.27 (95 % CI 0.90-1.80; P = 0.17) for fall (September-November). Other risk factors for AML included high fetal growth, high gestational age at birth, and low maternal education level. These findings did not vary by sex or age at diagnosis. Sex, birth order, parental age, and parental country of birth were not associated with AML. In this large cohort study, birth in winter was associated with increased risk of AML in childhood through young adulthood, possibly related to immunologic effects of early infectious exposures compared with summer birth. These findings warrant further investigation of the role of seasonally varying perinatal exposures in the etiology of AML. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8767570
- author
- Crump, Casey ; Sundquist, Jan LU ; Sieh, Weiva ; Winkleby, Marilyn A. and Sundquist, Kristina LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cohort studies, Fetal development, Gestational age, Leukemia, Risk, factors, Seasons
- in
- European Journal of Epidemiology
- volume
- 30
- issue
- 12
- pages
- 1277 - 1285
- publisher
- Springer
- external identifiers
-
- wos:000367331900005
- scopus:84952639445
- pmid:26113060
- ISSN
- 1573-7284
- DOI
- 10.1007/s10654-015-0063-0
- language
- English
- LU publication?
- yes
- id
- 192f1e87-3d0b-4381-ba8c-655ef4c24f34 (old id 8767570)
- date added to LUP
- 2016-04-01 11:04:56
- date last changed
- 2022-04-28 06:58:43
@article{192f1e87-3d0b-4381-ba8c-655ef4c24f34, abstract = {{Infectious etiologies have been hypothesized for acute leukemias because of their high incidence in early childhood, but have seldom been examined for acute myeloid leukemia (AML). We conducted the first large cohort study to examine perinatal factors including season of birth, a proxy for perinatal infectious exposures, and risk of AML in childhood through young adulthood. A national cohort of 3,569,333 persons without Down syndrome who were born in Sweden in 1973-2008 were followed up for AML incidence through 2010 (maximum age 38 years). There were 315 AML cases in 69.7 million person-years of follow-up. We found a sinusoidal pattern in AML risk by season of birth (P < 0.001), with peak risk among persons born in winter. Relative to persons born in summer (June-August), incidence rate ratios for AML were 1.72 (95 % CI 1.25-2.38; P = 0.001) for winter (December-February), 1.37 (95 % CI 0.99-1.90; P = 0.06) for spring (March-May), and 1.27 (95 % CI 0.90-1.80; P = 0.17) for fall (September-November). Other risk factors for AML included high fetal growth, high gestational age at birth, and low maternal education level. These findings did not vary by sex or age at diagnosis. Sex, birth order, parental age, and parental country of birth were not associated with AML. In this large cohort study, birth in winter was associated with increased risk of AML in childhood through young adulthood, possibly related to immunologic effects of early infectious exposures compared with summer birth. These findings warrant further investigation of the role of seasonally varying perinatal exposures in the etiology of AML.}}, author = {{Crump, Casey and Sundquist, Jan and Sieh, Weiva and Winkleby, Marilyn A. and Sundquist, Kristina}}, issn = {{1573-7284}}, keywords = {{Cohort studies; Fetal development; Gestational age; Leukemia; Risk; factors; Seasons}}, language = {{eng}}, number = {{12}}, pages = {{1277--1285}}, publisher = {{Springer}}, series = {{European Journal of Epidemiology}}, title = {{Perinatal risk factors for acute myeloid leukemia}}, url = {{http://dx.doi.org/10.1007/s10654-015-0063-0}}, doi = {{10.1007/s10654-015-0063-0}}, volume = {{30}}, year = {{2015}}, }