Comparative analysis of the effects of neurotrophic factors CDNF and GDNF in a nonhuman primate model of Parkinson’s disease
Garea-Rodríguez, Enrique ; Eesmaa, Ave ; Lindholm, Päivi K ; Schlumbohm, Christina ; König, Jessica ; Meller, Birgit ; Krieglstein, Kerstin ; Helms, Gunther LU
; Saarma, Mart
and Fuchs, Eberhard
(2016)
In PLoS ONE
11(2).
p.1-21
- Abstract
- Cerebral dopamine neurotrophic factor (CDNF) belongs to a newly discovered family of evolutionarily conserved neurotrophic factors.We demonstrate for the first time a therapeutic effect of CDNF in a unilateral 6-hydroxydopamine (6-OHDA) lesion model of Parkinson’s disease in marmoset monkeys. Furthermore, we tested the impact of high chronic doses of human recombinant CDNF on unlesionedmonkeys and analyzed the amino acid sequence ofmarmoset CDNF. The severity of 6-OHDA lesions and treatment effects weremonitored in vivo
using 123I-FP-CIT (DaTSCAN) SPECT. Quantitative analysis of 123I-FP-CIT SPECT showed a significant increase of dopamine transporter binding activity in lesioned animals treated with
CDNF. Glial cell... (More) - Cerebral dopamine neurotrophic factor (CDNF) belongs to a newly discovered family of evolutionarily conserved neurotrophic factors.We demonstrate for the first time a therapeutic effect of CDNF in a unilateral 6-hydroxydopamine (6-OHDA) lesion model of Parkinson’s disease in marmoset monkeys. Furthermore, we tested the impact of high chronic doses of human recombinant CDNF on unlesionedmonkeys and analyzed the amino acid sequence ofmarmoset CDNF. The severity of 6-OHDA lesions and treatment effects weremonitored in vivo
using 123I-FP-CIT (DaTSCAN) SPECT. Quantitative analysis of 123I-FP-CIT SPECT showed a significant increase of dopamine transporter binding activity in lesioned animals treated with
CDNF. Glial cell line-derived neurotrophic factor (GDNF), a well-characterized and potent neurotrophic factor for dopamine neurons, served as a control in a parallel comparison with CDNF. By contrast with CDNF, only single animals responded to the treatment with GDNF, but no statistical difference was observed in the GDNF group. However, increased numbers of tyrosine hydroxylase immunoreactive neurons, observed within the lesioned caudate nucleus of GDNF-treated animals, indicate a strong bioactive potential of GDNF. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8772474
- author
- Garea-Rodríguez, Enrique
; Eesmaa, Ave
; Lindholm, Päivi K
; Schlumbohm, Christina
; König, Jessica
; Meller, Birgit
; Krieglstein, Kerstin
; Helms, Gunther
LU
; Saarma, Mart
and Fuchs, Eberhard
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 11
- issue
- 2
- pages
- 1 - 21
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- scopus:84960977115
- pmid:26901822
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0149776
- project
- Structural brain MRI and SPECT of common marmosets using clinical scanners
- language
- English
- LU publication?
- yes
- id
- 3f6edcf1-3ea2-4e17-8f34-538c5b2e2cac (old id 8772474)
- date added to LUP
- 2016-04-01 14:38:23
- date last changed
- 2022-03-30 02:20:20
@article{3f6edcf1-3ea2-4e17-8f34-538c5b2e2cac,
abstract = {{Cerebral dopamine neurotrophic factor (CDNF) belongs to a newly discovered family of evolutionarily conserved neurotrophic factors.We demonstrate for the first time a therapeutic effect of CDNF in a unilateral 6-hydroxydopamine (6-OHDA) lesion model of Parkinson’s disease in marmoset monkeys. Furthermore, we tested the impact of high chronic doses of human recombinant CDNF on unlesionedmonkeys and analyzed the amino acid sequence ofmarmoset CDNF. The severity of 6-OHDA lesions and treatment effects weremonitored in vivo<br/><br>
using 123I-FP-CIT (DaTSCAN) SPECT. Quantitative analysis of 123I-FP-CIT SPECT showed a significant increase of dopamine transporter binding activity in lesioned animals treated with<br/><br>
CDNF. Glial cell line-derived neurotrophic factor (GDNF), a well-characterized and potent neurotrophic factor for dopamine neurons, served as a control in a parallel comparison with CDNF. By contrast with CDNF, only single animals responded to the treatment with GDNF, but no statistical difference was observed in the GDNF group. However, increased numbers of tyrosine hydroxylase immunoreactive neurons, observed within the lesioned caudate nucleus of GDNF-treated animals, indicate a strong bioactive potential of GDNF.}},
author = {{Garea-Rodríguez, Enrique and Eesmaa, Ave and Lindholm, Päivi K and Schlumbohm, Christina and König, Jessica and Meller, Birgit and Krieglstein, Kerstin and Helms, Gunther and Saarma, Mart and Fuchs, Eberhard}},
issn = {{1932-6203}},
language = {{eng}},
number = {{2}},
pages = {{1--21}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{Comparative analysis of the effects of neurotrophic factors CDNF and GDNF in a nonhuman primate model of Parkinson’s disease}},
url = {{https://lup.lub.lu.se/search/files/4080792/8772498.PDF}},
doi = {{10.1371/journal.pone.0149776}},
volume = {{11}},
year = {{2016}},
}