Treatment of acute neonatal bacterial conjunctivitis: a comparison of fucidic acid to chloramphenicol eye drops
(2002) In Acta Ophthalmologica Scandinavica 80(2). p.183-187- Abstract
- Purpose: To compare the clinical and bacteriological effects of fucidic acid (Fucithalmic(R): 1.0%) and chloramphenicol (Minims(R): 0.5%) eye drops in neonates with a clinical diagnosis of acute conjunctivitis of suspected bacterial origin. Methods: A total of 456 newborns with gestational age > 32 weeks with acute conjunctivitis of suspected bacterial origin acquired within the first 28 days of life were included in the study. They were randomly assigned to a 7-day treatment with eye drops using either fucidic acid (1.0%) (Fucithalmic(R)) applied or chloramphenicol (0.5%) (Minims(R) Chloramphenicol) applied twice per day six times per day. The subjects were followed up with two visits (on days 1 and 8) and by telephone 2 weeks after... (More)
- Purpose: To compare the clinical and bacteriological effects of fucidic acid (Fucithalmic(R): 1.0%) and chloramphenicol (Minims(R): 0.5%) eye drops in neonates with a clinical diagnosis of acute conjunctivitis of suspected bacterial origin. Methods: A total of 456 newborns with gestational age > 32 weeks with acute conjunctivitis of suspected bacterial origin acquired within the first 28 days of life were included in the study. They were randomly assigned to a 7-day treatment with eye drops using either fucidic acid (1.0%) (Fucithalmic(R)) applied or chloramphenicol (0.5%) (Minims(R) Chloramphenicol) applied twice per day six times per day. The subjects were followed up with two visits (on days 1 and 8) and by telephone 2 weeks after the end of treatment. Results: Eighty-nine per cent of the neonates treated with Fucithalmic(R) were cured, compared to 87.9% of those treated with Minims(R) Chloramphenicol (n.s). The drug was used as instructed in 90.7% of patients treated with Fucithalmic(R) and in 78.0% of those treated with Minims(R) Chloramphenicol (P < 0.001). Conclusion: Treating neonatal conjunctivitis with fucidic acid is easier than with chloramphenicol and is equally effective. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/893557
- author
- Normann, EK ; Bakken, O ; Peltola, J ; Andréasson, Bengt LU ; Buhl, S ; Sigg, P and Nielsen, K
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- fucidic acid, conjunctivitis, neonatal, chloramphenicol
- in
- Acta Ophthalmologica Scandinavica
- volume
- 80
- issue
- 2
- pages
- 183 - 187
- publisher
- Wiley
- external identifiers
-
- wos:000175092800012
- pmid:11952486
- scopus:0036123819
- ISSN
- 1395-3907
- DOI
- 10.1034/j.1600-0420.2002.800212.x
- language
- English
- LU publication?
- yes
- id
- 2fdc3002-78c7-4cba-ad8c-4b898887eefe (old id 893557)
- date added to LUP
- 2016-04-01 15:36:53
- date last changed
- 2022-02-12 08:49:04
@article{2fdc3002-78c7-4cba-ad8c-4b898887eefe, abstract = {{Purpose: To compare the clinical and bacteriological effects of fucidic acid (Fucithalmic(R): 1.0%) and chloramphenicol (Minims(R): 0.5%) eye drops in neonates with a clinical diagnosis of acute conjunctivitis of suspected bacterial origin. Methods: A total of 456 newborns with gestational age > 32 weeks with acute conjunctivitis of suspected bacterial origin acquired within the first 28 days of life were included in the study. They were randomly assigned to a 7-day treatment with eye drops using either fucidic acid (1.0%) (Fucithalmic(R)) applied or chloramphenicol (0.5%) (Minims(R) Chloramphenicol) applied twice per day six times per day. The subjects were followed up with two visits (on days 1 and 8) and by telephone 2 weeks after the end of treatment. Results: Eighty-nine per cent of the neonates treated with Fucithalmic(R) were cured, compared to 87.9% of those treated with Minims(R) Chloramphenicol (n.s). The drug was used as instructed in 90.7% of patients treated with Fucithalmic(R) and in 78.0% of those treated with Minims(R) Chloramphenicol (P < 0.001). Conclusion: Treating neonatal conjunctivitis with fucidic acid is easier than with chloramphenicol and is equally effective.}}, author = {{Normann, EK and Bakken, O and Peltola, J and Andréasson, Bengt and Buhl, S and Sigg, P and Nielsen, K}}, issn = {{1395-3907}}, keywords = {{fucidic acid; conjunctivitis; neonatal; chloramphenicol}}, language = {{eng}}, number = {{2}}, pages = {{183--187}}, publisher = {{Wiley}}, series = {{Acta Ophthalmologica Scandinavica}}, title = {{Treatment of acute neonatal bacterial conjunctivitis: a comparison of fucidic acid to chloramphenicol eye drops}}, url = {{http://dx.doi.org/10.1034/j.1600-0420.2002.800212.x}}, doi = {{10.1034/j.1600-0420.2002.800212.x}}, volume = {{80}}, year = {{2002}}, }