No relation between biomarkers at age 47-49 and aortic diameter after 14-19 years of follow-up - a population-based study
(2017) In Vasa - European Journal of Vascular Medicine 46(4). p.291-295- Abstract
BACKGROUND: Biomarkers reflecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA.
PROBANDS AND METHODS: To evaluate potential relationships between biomarkers and aortic dilatation after long-term follow-up, levels of C-reactive protein (CRP), proneurotensin (PNT), copeptin (CPT), lipoprotein-associated phospholipase 2 (Lp-PLA2), cystatin C (Cyst C), midregional proatrial natriuretic peptide (MR-proANP), and midregional proadrenomedullin (MR-proADM) were measured in 117 subjects (114 [97 %] men)... (More)
BACKGROUND: Biomarkers reflecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA.
PROBANDS AND METHODS: To evaluate potential relationships between biomarkers and aortic dilatation after long-term follow-up, levels of C-reactive protein (CRP), proneurotensin (PNT), copeptin (CPT), lipoprotein-associated phospholipase 2 (Lp-PLA2), cystatin C (Cyst C), midregional proatrial natriuretic peptide (MR-proANP), and midregional proadrenomedullin (MR-proADM) were measured in 117 subjects (114 [97 %] men) aged 47-49 in a prospective population-based cohort study, and related to aortic diameter at US examination of the aorta after 14-19 years of follow-up.
RESULTS: Biomarker levels at baseline did not correlate with aortic diameter after 14-19 years of follow up (CRP [r = 0.153], PNT [r = 0.070], CPT [r = -.156], Lp-PLA2 [r = .024], Cyst C [r = -.015], MR-proANP [r = 0.014], MR-proADM [r = -.117]). Adjusting for age and smoking at baseline in a linear regression model did not reveal any significant correlations.
CONCLUSIONS: Tested biomarker levels at age 47-49 were not associated with aortic diameter at ultrasound examination after 14-19 years of follow-up. If there are relationships between these biomarkers and aortic dilatation, they are not relevant until closer to AAA diagnosis.
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- author
- Taimour, Soumia LU ; Zarrouk, Moncef LU ; Holst, Jan LU ; Melander, Olle LU ; Engström, Gunnar LU ; Smith, J. Gustav LU and Gottsäter, Anders LU
- organization
-
- Vascular Diseases - Clinical Research (research group)
- Cardiovascular Research - Hypertension (research group)
- Department of Clinical Sciences, Malmö
- Cardiovascular Research - Epidemiology (research group)
- Cardiology
- Cardiovascular Epigenetics (research group)
- Molecular Epidemiology and Cardiology (research group)
- Heart Failure and Mechanical Support (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- publishing date
- 2017-04-27
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Biomarkers, Aortic diameter, Aortic Aneurysm
- in
- Vasa - European Journal of Vascular Medicine
- volume
- 46
- issue
- 4
- pages
- 5 pages
- publisher
- Verlag Hans Huber
- external identifiers
-
- scopus:85024492655
- wos:000408059800009
- pmid:28447918
- ISSN
- 0301-1526
- DOI
- 10.1024/0301-1526/a000632
- language
- English
- LU publication?
- yes
- id
- 89b3ddb7-71f7-4d56-b910-c44767f5c7c6
- date added to LUP
- 2017-05-29 11:28:36
- date last changed
- 2024-08-19 23:15:07
@article{89b3ddb7-71f7-4d56-b910-c44767f5c7c6, abstract = {{<p>BACKGROUND: Biomarkers reflecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA.</p><p>PROBANDS AND METHODS: To evaluate potential relationships between biomarkers and aortic dilatation after long-term follow-up, levels of C-reactive protein (CRP), proneurotensin (PNT), copeptin (CPT), lipoprotein-associated phospholipase 2 (Lp-PLA2), cystatin C (Cyst C), midregional proatrial natriuretic peptide (MR-proANP), and midregional proadrenomedullin (MR-proADM) were measured in 117 subjects (114 [97 %] men) aged 47-49 in a prospective population-based cohort study, and related to aortic diameter at US examination of the aorta after 14-19 years of follow-up.</p><p>RESULTS: Biomarker levels at baseline did not correlate with aortic diameter after 14-19 years of follow up (CRP [r = 0.153], PNT [r = 0.070], CPT [r = -.156], Lp-PLA2 [r = .024], Cyst C [r = -.015], MR-proANP [r = 0.014], MR-proADM [r = -.117]). Adjusting for age and smoking at baseline in a linear regression model did not reveal any significant correlations.</p><p>CONCLUSIONS: Tested biomarker levels at age 47-49 were not associated with aortic diameter at ultrasound examination after 14-19 years of follow-up. If there are relationships between these biomarkers and aortic dilatation, they are not relevant until closer to AAA diagnosis.</p>}}, author = {{Taimour, Soumia and Zarrouk, Moncef and Holst, Jan and Melander, Olle and Engström, Gunnar and Smith, J. Gustav and Gottsäter, Anders}}, issn = {{0301-1526}}, keywords = {{Biomarkers; Aortic diameter; Aortic Aneurysm}}, language = {{eng}}, month = {{04}}, number = {{4}}, pages = {{291--295}}, publisher = {{Verlag Hans Huber}}, series = {{Vasa - European Journal of Vascular Medicine}}, title = {{No relation between biomarkers at age 47-49 and aortic diameter after 14-19 years of follow-up - a population-based study}}, url = {{http://dx.doi.org/10.1024/0301-1526/a000632}}, doi = {{10.1024/0301-1526/a000632}}, volume = {{46}}, year = {{2017}}, }