HER2-encoded mir-4728 forms a receptor-independent circuit with miR-21-5p through the non-canonical poly(A) polymerase PAPD5
(2016) In Scientific Reports 6.- Abstract
We previously reported that the human HER2 gene encodes the intronic microRNA mir-4728, which is overexpressed together with its oncogenic host gene and may act independently of the HER2 receptor. More recently, we also reported that the oncogenic miR-21-5p is regulated by 3′ tailing and trimming by the non-canonical poly(A) polymerase PAPD5 and the ribonuclease PARN. Here we demonstrate a dual function for the HER2 locus in upregulation of miR-21-5p; while HER2 signalling activates transcription of mir-21, miR-4728-3p specifically stabilises miR-21-5p through inhibition of PAPD5. Our results establish a new and unexpected oncogenic role for the HER2 locus that is not currently being targeted by any anti-HER2 therapy.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/89c22698-07a5-4fd3-8769-1b5273315c64
- author
- Newie, Inga LU ; Søkilde, Rolf LU ; Persson, Helena LU ; Jacomasso, Thiago LU ; Gorbatenko, Andrej ; Borg, Åke LU ; De Hoon, Michiel ; Pedersen, Stine F. and Rovira, Carlos LU
- organization
- publishing date
- 2016-10-18
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 6
- article number
- 35664
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:84992027415
- pmid:27752128
- wos:000385584700001
- ISSN
- 2045-2322
- DOI
- 10.1038/srep35664
- language
- English
- LU publication?
- yes
- id
- 89c22698-07a5-4fd3-8769-1b5273315c64
- date added to LUP
- 2016-11-14 13:20:25
- date last changed
- 2024-09-21 02:51:34
@article{89c22698-07a5-4fd3-8769-1b5273315c64, abstract = {{<p>We previously reported that the human HER2 gene encodes the intronic microRNA mir-4728, which is overexpressed together with its oncogenic host gene and may act independently of the HER2 receptor. More recently, we also reported that the oncogenic miR-21-5p is regulated by 3′ tailing and trimming by the non-canonical poly(A) polymerase PAPD5 and the ribonuclease PARN. Here we demonstrate a dual function for the HER2 locus in upregulation of miR-21-5p; while HER2 signalling activates transcription of mir-21, miR-4728-3p specifically stabilises miR-21-5p through inhibition of PAPD5. Our results establish a new and unexpected oncogenic role for the HER2 locus that is not currently being targeted by any anti-HER2 therapy.</p>}}, author = {{Newie, Inga and Søkilde, Rolf and Persson, Helena and Jacomasso, Thiago and Gorbatenko, Andrej and Borg, Åke and De Hoon, Michiel and Pedersen, Stine F. and Rovira, Carlos}}, issn = {{2045-2322}}, language = {{eng}}, month = {{10}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{HER2-encoded mir-4728 forms a receptor-independent circuit with miR-21-5p through the non-canonical poly(A) polymerase PAPD5}}, url = {{http://dx.doi.org/10.1038/srep35664}}, doi = {{10.1038/srep35664}}, volume = {{6}}, year = {{2016}}, }