Genetic dissection of autoimmune type I diabetes in the BB rat
(1992) In Nature Genetics 2(1). p.56-60- Abstract
The BB rat is among the best models of insulin−dependent diabetes mellitus — with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T−cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.
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https://lup.lub.lu.se/record/94618191-25f6-4338-9338-1f18050fa9e7
- author
- Jacob, Howard J. ; Pettersson, Anna ; Wilson, Deborah ; Mao, Yipei ; Lernmark, Åke LU and Lander, Eric S.
- publishing date
- 1992-01-01
- type
- Contribution to journal
- publication status
- published
- in
- Nature Genetics
- volume
- 2
- issue
- 1
- pages
- 56 - 60
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:0026922594
- pmid:1303251
- ISSN
- 1061-4036
- DOI
- 10.1038/ng0992-56
- language
- English
- LU publication?
- no
- id
- 94618191-25f6-4338-9338-1f18050fa9e7
- date added to LUP
- 2019-09-11 09:31:28
- date last changed
- 2024-03-13 08:21:28
@article{94618191-25f6-4338-9338-1f18050fa9e7, abstract = {{<p>The BB rat is among the best models of insulin−dependent diabetes mellitus — with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T−cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.</p>}}, author = {{Jacob, Howard J. and Pettersson, Anna and Wilson, Deborah and Mao, Yipei and Lernmark, Åke and Lander, Eric S.}}, issn = {{1061-4036}}, language = {{eng}}, month = {{01}}, number = {{1}}, pages = {{56--60}}, publisher = {{Nature Publishing Group}}, series = {{Nature Genetics}}, title = {{Genetic dissection of autoimmune type I diabetes in the BB rat}}, url = {{http://dx.doi.org/10.1038/ng0992-56}}, doi = {{10.1038/ng0992-56}}, volume = {{2}}, year = {{1992}}, }