Augmenting Glioblastoma Chemotherapy with Polymers
(2018) In ACS Chemical Neuroscience 9(1). p.8-10- Abstract
Chemotherapeutics are vital for treating brain tumors such as glioblastoma, an aggressive and prolific cancer predominantly treated with DNA alkylating agents. The efficacy of antiglioblastoma drugs, such as temozolomide, is limited by their rapid clearance and instability under normal physiological conditions. Both local and systemic polymer-based therapeutics have shown promise for treating many cancers, and as such there is a growing interest in applying polymer techniques to augment the efficacy and stability of glioblastoma chemotherapeutics. Notably, brain tumor chemotherapy presents unique challenges and will require tailored delivery systems to develop markedly improved treatments.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/96fc7be5-e4a0-4417-baa0-946a55595423
- author
- Skinner, Matthew ; Ward, Sarah M. ; Nilsson, Carol L. LU and Emrick, Todd
- organization
- publishing date
- 2018-01-17
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- brain tumor, chemotherapy, Glioblastoma
- in
- ACS Chemical Neuroscience
- volume
- 9
- issue
- 1
- pages
- 3 pages
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- pmid:28594164
- scopus:85040648021
- ISSN
- 1948-7193
- DOI
- 10.1021/acschemneuro.7b00168
- language
- English
- LU publication?
- yes
- id
- 96fc7be5-e4a0-4417-baa0-946a55595423
- date added to LUP
- 2018-01-30 10:59:39
- date last changed
- 2024-03-01 13:19:53
@article{96fc7be5-e4a0-4417-baa0-946a55595423,
abstract = {{<p>Chemotherapeutics are vital for treating brain tumors such as glioblastoma, an aggressive and prolific cancer predominantly treated with DNA alkylating agents. The efficacy of antiglioblastoma drugs, such as temozolomide, is limited by their rapid clearance and instability under normal physiological conditions. Both local and systemic polymer-based therapeutics have shown promise for treating many cancers, and as such there is a growing interest in applying polymer techniques to augment the efficacy and stability of glioblastoma chemotherapeutics. Notably, brain tumor chemotherapy presents unique challenges and will require tailored delivery systems to develop markedly improved treatments.</p>}},
author = {{Skinner, Matthew and Ward, Sarah M. and Nilsson, Carol L. and Emrick, Todd}},
issn = {{1948-7193}},
keywords = {{brain tumor; chemotherapy; Glioblastoma}},
language = {{eng}},
month = {{01}},
number = {{1}},
pages = {{8--10}},
publisher = {{The American Chemical Society (ACS)}},
series = {{ACS Chemical Neuroscience}},
title = {{Augmenting Glioblastoma Chemotherapy with Polymers}},
url = {{http://dx.doi.org/10.1021/acschemneuro.7b00168}},
doi = {{10.1021/acschemneuro.7b00168}},
volume = {{9}},
year = {{2018}},
}