SNPs related to vitamin D and breast cancer risk : A case-control study
(2018) In Breast Cancer Research 20(1).- Abstract
Background: It has been suggested that vitamin D might protect from breast cancer, although studies on levels of vitamin D in association with breast cancer have been inconsistent. Genome-wide association studies (GWASs) have identified several single-nucleotide polymorphisms (SNPs) to be associated with vitamin D. The aim of this study was to investigate such vitamin D-SNP associations in relation to subsequent breast cancer risk. A first step included verification of these SNPs as determinants of vitamin D levels. Methods: The Malmö Diet and Cancer Study included 17,035 women in a prospective cohort. Genotyping was performed and was successful in 4058 nonrelated women from this cohort in which 865 were diagnosed with breast cancer.... (More)
Background: It has been suggested that vitamin D might protect from breast cancer, although studies on levels of vitamin D in association with breast cancer have been inconsistent. Genome-wide association studies (GWASs) have identified several single-nucleotide polymorphisms (SNPs) to be associated with vitamin D. The aim of this study was to investigate such vitamin D-SNP associations in relation to subsequent breast cancer risk. A first step included verification of these SNPs as determinants of vitamin D levels. Methods: The Malmö Diet and Cancer Study included 17,035 women in a prospective cohort. Genotyping was performed and was successful in 4058 nonrelated women from this cohort in which 865 were diagnosed with breast cancer. Levels of vitamin D (25-hydroxyvitamin D) were available for 700 of the breast cancer cases and 643 of unaffected control subjects. SNPs previously associated with vitamin D in GWASs were identified. Logistic regression analyses yielding ORs with 95% CIs were performed to investigate selected SNPs in relation to low levels of vitamin D (below median) as well as to the risk of breast cancer. Results: The majority of SNPs previously associated with levels of vitamin D showed a statistically significant association with circulating vitamin D levels. Heterozygotes of one SNP (rs12239582) were found to have a statistically significant association with a low risk of breast cancer (OR 0.82, 95% CI 0.68-0.99), and minor homozygotes of the same SNP were found to have a tendency towards a low risk of being in the group with low vitamin D levels (OR 0.72, 95% CI 0.52-1.00). Results from stratified analyses showed diverse associations with breast cancer risk for a few of the tested SNPs, depending on whether vitamin D level was high or low. Conclusions: SNPs associated with vitamin D may also be associated with the risk of breast cancer. Even if such a risk is small, the allele frequency of the SNP variants is high, and therefore the population attributable risk could be substantial. It is also possible that vitamin D levels may interact with genomic traits with regard to breast cancer risk.
(Less)
- author
- Huss, Linnea LU ; Butt, Salma Tunå LU ; Almgren, Peter LU ; Borgquist, Signe LU ; Brandt, Jasmine LU ; Försti, Asta LU ; Melander, Olle LU and Manjer, Jonas LU
- organization
- publishing date
- 2018-01-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Breast cancer, Polymorphism, SNP, Vitamin D
- in
- Breast Cancer Research
- volume
- 20
- issue
- 1
- article number
- 1
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85039838452
- pmid:29291743
- ISSN
- 1465-5411
- DOI
- 10.1186/s13058-017-0925-3
- language
- English
- LU publication?
- yes
- id
- 9bacaf40-378a-42aa-aa8d-d29950c325de
- date added to LUP
- 2018-01-23 14:58:35
- date last changed
- 2024-07-08 08:23:20
@article{9bacaf40-378a-42aa-aa8d-d29950c325de, abstract = {{<p>Background: It has been suggested that vitamin D might protect from breast cancer, although studies on levels of vitamin D in association with breast cancer have been inconsistent. Genome-wide association studies (GWASs) have identified several single-nucleotide polymorphisms (SNPs) to be associated with vitamin D. The aim of this study was to investigate such vitamin D-SNP associations in relation to subsequent breast cancer risk. A first step included verification of these SNPs as determinants of vitamin D levels. Methods: The Malmö Diet and Cancer Study included 17,035 women in a prospective cohort. Genotyping was performed and was successful in 4058 nonrelated women from this cohort in which 865 were diagnosed with breast cancer. Levels of vitamin D (25-hydroxyvitamin D) were available for 700 of the breast cancer cases and 643 of unaffected control subjects. SNPs previously associated with vitamin D in GWASs were identified. Logistic regression analyses yielding ORs with 95% CIs were performed to investigate selected SNPs in relation to low levels of vitamin D (below median) as well as to the risk of breast cancer. Results: The majority of SNPs previously associated with levels of vitamin D showed a statistically significant association with circulating vitamin D levels. Heterozygotes of one SNP (rs12239582) were found to have a statistically significant association with a low risk of breast cancer (OR 0.82, 95% CI 0.68-0.99), and minor homozygotes of the same SNP were found to have a tendency towards a low risk of being in the group with low vitamin D levels (OR 0.72, 95% CI 0.52-1.00). Results from stratified analyses showed diverse associations with breast cancer risk for a few of the tested SNPs, depending on whether vitamin D level was high or low. Conclusions: SNPs associated with vitamin D may also be associated with the risk of breast cancer. Even if such a risk is small, the allele frequency of the SNP variants is high, and therefore the population attributable risk could be substantial. It is also possible that vitamin D levels may interact with genomic traits with regard to breast cancer risk.</p>}}, author = {{Huss, Linnea and Butt, Salma Tunå and Almgren, Peter and Borgquist, Signe and Brandt, Jasmine and Försti, Asta and Melander, Olle and Manjer, Jonas}}, issn = {{1465-5411}}, keywords = {{Breast cancer; Polymorphism; SNP; Vitamin D}}, language = {{eng}}, month = {{01}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{Breast Cancer Research}}, title = {{SNPs related to vitamin D and breast cancer risk : A case-control study}}, url = {{http://dx.doi.org/10.1186/s13058-017-0925-3}}, doi = {{10.1186/s13058-017-0925-3}}, volume = {{20}}, year = {{2018}}, }