Localisation of secretory leucocyte proteinase inhibitor mRNA in nasal mucosa
(1994) In Acta Oto-Laryngologica 114(2). p.199-202- Abstract
Human secretory leucocyte proteinase inhibitor (SLPI) is a low-molecular weight, acid-stable inhibitor of polymorphnuclear granulocyte elastase and cathepsin G. Previous reports have demonstrated the existence of SLPI in the respiratory tract, salivary glands and cervical mucosa. Positive staining for SLPI using immunohistochemical techniques has been reported in serous glands in nasal mucosa. We now confirm this observation and show, using in situ hybridization, that the pattern of expression of mRNA corresponds to the distribution of the encoded protein, SLPI. This, together with the high concentration of SLPI in nasal secretions, confirms the hypothesis of a local production of SLPI in the mucous membranes.
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https://lup.lub.lu.se/record/9ee75d19-cd9e-4b8b-adef-f60238242e2e
- author
- Westin, Ulla LU ; Fryksmark, Ulla ; Polling, Åsa and Ohlsson, Kjell
- organization
- publishing date
- 1994
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- MRNA, Nasal mucosa, Protease inhibitor, Serous glands, SLPI
- in
- Acta Oto-Laryngologica
- volume
- 114
- issue
- 2
- pages
- 199 - 202
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:0028353950
- pmid:7515550
- ISSN
- 0001-6489
- DOI
- 10.3109/00016489409126042
- language
- English
- LU publication?
- yes
- id
- 9ee75d19-cd9e-4b8b-adef-f60238242e2e
- date added to LUP
- 2017-02-13 16:12:22
- date last changed
- 2024-01-13 13:53:32
@article{9ee75d19-cd9e-4b8b-adef-f60238242e2e, abstract = {{<p>Human secretory leucocyte proteinase inhibitor (SLPI) is a low-molecular weight, acid-stable inhibitor of polymorphnuclear granulocyte elastase and cathepsin G. Previous reports have demonstrated the existence of SLPI in the respiratory tract, salivary glands and cervical mucosa. Positive staining for SLPI using immunohistochemical techniques has been reported in serous glands in nasal mucosa. We now confirm this observation and show, using in situ hybridization, that the pattern of expression of mRNA corresponds to the distribution of the encoded protein, SLPI. This, together with the high concentration of SLPI in nasal secretions, confirms the hypothesis of a local production of SLPI in the mucous membranes.</p>}}, author = {{Westin, Ulla and Fryksmark, Ulla and Polling, Åsa and Ohlsson, Kjell}}, issn = {{0001-6489}}, keywords = {{MRNA; Nasal mucosa; Protease inhibitor; Serous glands; SLPI}}, language = {{eng}}, number = {{2}}, pages = {{199--202}}, publisher = {{Taylor & Francis}}, series = {{Acta Oto-Laryngologica}}, title = {{Localisation of secretory leucocyte proteinase inhibitor mRNA in nasal mucosa}}, url = {{http://dx.doi.org/10.3109/00016489409126042}}, doi = {{10.3109/00016489409126042}}, volume = {{114}}, year = {{1994}}, }