Pregnancy outcomes from the Branded glatiramer acetate pregnancy database
(2018) In International Journal of MS Care 20(1). p.9-14- Abstract
Background: Appropriate counseling and treatment for women with multiple sclerosis (MS) who may become pregnant requires an understanding of the effects of exposure to disease-modifying therapies (DMTs) during pregnancy. Current reports and studies are limited in their usefulness, mostly by small sample size. Branded glatiramer acetate (GA) is a DMT approved for the treatment of relapsing forms of MS. For more than 2 decades, it has been shown to be efficacious and to have a favorable safety profile. The Teva Pharmaceutical Industries Ltd global pharmacovigilance database comprises data from more than 7000 pregnancies, during which women with MS were exposed to treatment with branded GA. Methods: We analyzed data from Teva's global... (More)
Background: Appropriate counseling and treatment for women with multiple sclerosis (MS) who may become pregnant requires an understanding of the effects of exposure to disease-modifying therapies (DMTs) during pregnancy. Current reports and studies are limited in their usefulness, mostly by small sample size. Branded glatiramer acetate (GA) is a DMT approved for the treatment of relapsing forms of MS. For more than 2 decades, it has been shown to be efficacious and to have a favorable safety profile. The Teva Pharmaceutical Industries Ltd global pharmacovigilance database comprises data from more than 7000 pregnancies, during which women with MS were exposed to treatment with branded GA. Methods: We analyzed data from Teva's global pharmacovigilance database. Pregnancy outcomes for patients treated with branded GA were compared with reference rates of abnormal pregnancy outcomes reported in two large registries representing the general population. Results: Pregnancies exposed to branded GA were not at higher risk for congenital anomalies than what is expected in the general population. Conclusions: These data provide evidence that branded GA exposure during pregnancy seems safe, without teratogenic effect.
(Less)
- author
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of MS Care
- volume
- 20
- issue
- 1
- pages
- 6 pages
- publisher
- Consortium of Multiple Sclerosis Centers (CMSC)
- external identifiers
-
- scopus:85042466095
- pmid:29507538
- ISSN
- 1537-2073
- DOI
- 10.7224/1537-2073.2016-079
- language
- English
- LU publication?
- no
- id
- 9f6db950-8332-4b99-a968-13c3952bfdfe
- date added to LUP
- 2018-03-09 10:25:19
- date last changed
- 2024-04-30 05:01:44
@article{9f6db950-8332-4b99-a968-13c3952bfdfe, abstract = {{<p>Background: Appropriate counseling and treatment for women with multiple sclerosis (MS) who may become pregnant requires an understanding of the effects of exposure to disease-modifying therapies (DMTs) during pregnancy. Current reports and studies are limited in their usefulness, mostly by small sample size. Branded glatiramer acetate (GA) is a DMT approved for the treatment of relapsing forms of MS. For more than 2 decades, it has been shown to be efficacious and to have a favorable safety profile. The Teva Pharmaceutical Industries Ltd global pharmacovigilance database comprises data from more than 7000 pregnancies, during which women with MS were exposed to treatment with branded GA. Methods: We analyzed data from Teva's global pharmacovigilance database. Pregnancy outcomes for patients treated with branded GA were compared with reference rates of abnormal pregnancy outcomes reported in two large registries representing the general population. Results: Pregnancies exposed to branded GA were not at higher risk for congenital anomalies than what is expected in the general population. Conclusions: These data provide evidence that branded GA exposure during pregnancy seems safe, without teratogenic effect.</p>}}, author = {{Sandberg-Wollheim, Magnhild and Neudorfer, Orit and Grinspan, Augusto and Weinstock-Guttman, Bianca and Haas, Judith and Izquierdo, Guillermo and Riley, Claire and Ross, Amy Perrin and Baruch, Peleg and Drillman, Talya and Coyle, Patricia K.}}, issn = {{1537-2073}}, language = {{eng}}, number = {{1}}, pages = {{9--14}}, publisher = {{Consortium of Multiple Sclerosis Centers (CMSC)}}, series = {{International Journal of MS Care}}, title = {{Pregnancy outcomes from the Branded glatiramer acetate pregnancy database}}, url = {{http://dx.doi.org/10.7224/1537-2073.2016-079}}, doi = {{10.7224/1537-2073.2016-079}}, volume = {{20}}, year = {{2018}}, }