Extreme sleep pattern in Lewy body dementia : A hypothalamic matter?
(2019) In BMJ Case Reports 12(3).- Abstract
Excessive sleep during the night and for >2 hours during the day is part of the fluctuating wakefulness criterion of dementia with Lewy bodies (DLB). The phenomenon â € sleep days' is not uncommon in nursing homes. Here, we describe a woman who, for months, slept for 3 days and nights in a row and thereafter was awake for 3 days and nights. Electroencephalogram (EEG) showed slow background activity and increased delta activity. No epileptiform activity was detected. Polysomnography showed a severely disturbed, markedly fragmented sleep pattern. On her death, neuropathology revealed degeneration and loss of neurons along with α-synuclein-containing Lewy body inclusions and neurites in the substantia nigra, locus coeruleus,... (More)
Excessive sleep during the night and for >2 hours during the day is part of the fluctuating wakefulness criterion of dementia with Lewy bodies (DLB). The phenomenon â € sleep days' is not uncommon in nursing homes. Here, we describe a woman who, for months, slept for 3 days and nights in a row and thereafter was awake for 3 days and nights. Electroencephalogram (EEG) showed slow background activity and increased delta activity. No epileptiform activity was detected. Polysomnography showed a severely disturbed, markedly fragmented sleep pattern. On her death, neuropathology revealed degeneration and loss of neurons along with α-synuclein-containing Lewy body inclusions and neurites in the substantia nigra, locus coeruleus, hypothalamus, and neocortex, thus fulfilling the criteria of DLB, cortical type. We propose that the hypothalamic degeneration contributed significantly to the clinical profile in this case. We suggest that patients with sleep days should be investigated for other DLB signs.
(Less)
- author
- Londos, Elisabet LU ; Hansson, Oskar LU ; Rosén, Ingmar LU and Englund, Elisabet LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- memory disorders, sleep disorders (neurology)
- in
- BMJ Case Reports
- volume
- 12
- issue
- 3
- article number
- e228177
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:30852516
- scopus:85062712792
- ISSN
- 1757-790X
- DOI
- 10.1136/bcr-2018-228177
- language
- English
- LU publication?
- yes
- id
- a377aed3-50be-477d-961c-4e6a55981a92
- date added to LUP
- 2019-03-20 08:25:09
- date last changed
- 2024-09-17 16:09:59
@article{a377aed3-50be-477d-961c-4e6a55981a92, abstract = {{<p>Excessive sleep during the night and for >2 hours during the day is part of the fluctuating wakefulness criterion of dementia with Lewy bodies (DLB). The phenomenon â € sleep days' is not uncommon in nursing homes. Here, we describe a woman who, for months, slept for 3 days and nights in a row and thereafter was awake for 3 days and nights. Electroencephalogram (EEG) showed slow background activity and increased delta activity. No epileptiform activity was detected. Polysomnography showed a severely disturbed, markedly fragmented sleep pattern. On her death, neuropathology revealed degeneration and loss of neurons along with α-synuclein-containing Lewy body inclusions and neurites in the substantia nigra, locus coeruleus, hypothalamus, and neocortex, thus fulfilling the criteria of DLB, cortical type. We propose that the hypothalamic degeneration contributed significantly to the clinical profile in this case. We suggest that patients with sleep days should be investigated for other DLB signs.</p>}}, author = {{Londos, Elisabet and Hansson, Oskar and Rosén, Ingmar and Englund, Elisabet}}, issn = {{1757-790X}}, keywords = {{memory disorders; sleep disorders (neurology)}}, language = {{eng}}, number = {{3}}, publisher = {{BMJ Publishing Group}}, series = {{BMJ Case Reports}}, title = {{Extreme sleep pattern in Lewy body dementia : A hypothalamic matter?}}, url = {{http://dx.doi.org/10.1136/bcr-2018-228177}}, doi = {{10.1136/bcr-2018-228177}}, volume = {{12}}, year = {{2019}}, }