GFR-gränsen har sänkts för metformin vid typ 2-diabetes : Nya rekommendationer vid nedsatt njurfunktion och undersökning med jodkontrastmedel
(2018) In Läkartidningen 115(15).- Abstract
Treatment with metformin in type 2 diabetes mellitus-new routines when renal function is reduced and in connection with administration of iodine contrast media Metformin is eliminated through glomerular filtration and tubular secretion in the kidneys. New guidelines recommend use of metformin down to a GFR of 30 mL/min under the condition that the dose is adjusted. As the risk of inducing lactic acidosis is very low in connection with administration of iodine contrast media, new recommendations in Sweden say that metformin must be stopped only when GFR is below 45 mL/min. Determination of metformin levels in serum is useful to guide therapeutic dose when GFR is low but also to confirm that lactic acidosis is caused by metformin.
- Abstract (Swedish)
- Metformin is eliminated through glomerular filtration and tubular secretion in the kidneys. New guidelines recommend use of metformin down to a GFR of 30 mL/min under the condition that the dose is adjusted. As the risk of inducing lactic acidosis is very low in connection with administration of iodine contrast media, new recommendations in Sweden say that metformin must be stopped only when GFR is below 45 mL/min. Determination of metformin levels in serum is useful to guide therapeutic dose when GFR is low but also to confirm that lactic acidosis is caused by metformin.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/a4210e89-f9be-49ec-ad11-8e7a0fcc97e9
- author
- Sterner, Gunnar LU and Frid, Anders LU
- publishing date
- 2018-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Läkartidningen
- volume
- 115
- issue
- 15
- pages
- 1 pages
- publisher
- Swedish Medical Association
- external identifiers
-
- scopus:85045476863
- scopus:85058874352
- ISSN
- 0023-7205
- language
- Swedish
- LU publication?
- no
- id
- a4210e89-f9be-49ec-ad11-8e7a0fcc97e9
- alternative location
- http://www.lakartidningen.se/Klinik-och-vetenskap/Kommentar/2018/04/GFR-gransen-har-sankts-for-metformin-vid-typ-2-diabetes/
- date added to LUP
- 2018-04-24 15:58:58
- date last changed
- 2024-03-01 18:05:33
@article{a4210e89-f9be-49ec-ad11-8e7a0fcc97e9, abstract = {{<p>Treatment with metformin in type 2 diabetes mellitus-new routines when renal function is reduced and in connection with administration of iodine contrast media Metformin is eliminated through glomerular filtration and tubular secretion in the kidneys. New guidelines recommend use of metformin down to a GFR of 30 mL/min under the condition that the dose is adjusted. As the risk of inducing lactic acidosis is very low in connection with administration of iodine contrast media, new recommendations in Sweden say that metformin must be stopped only when GFR is below 45 mL/min. Determination of metformin levels in serum is useful to guide therapeutic dose when GFR is low but also to confirm that lactic acidosis is caused by metformin.</p>}}, author = {{Sterner, Gunnar and Frid, Anders}}, issn = {{0023-7205}}, language = {{swe}}, month = {{01}}, number = {{15}}, publisher = {{Swedish Medical Association}}, series = {{Läkartidningen}}, title = {{GFR-gränsen har sänkts för metformin vid typ 2-diabetes : Nya rekommendationer vid nedsatt njurfunktion och undersökning med jodkontrastmedel}}, url = {{http://www.lakartidningen.se/Klinik-och-vetenskap/Kommentar/2018/04/GFR-gransen-har-sankts-for-metformin-vid-typ-2-diabetes/}}, volume = {{115}}, year = {{2018}}, }