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The emerging alliance of sphingosine-1-phosphate signaling and immune cells: from basic mechanisms to implications in hypertension.

Don-Doncow, Nicholas LU ; Zhang, Yun LU ; Matuskova, Hana LU and Meissner, Anja LU (2019) In British Journal of Pharmacology 176(12). p.1989-2001
Abstract
The immune system plays a considerable role in hypertension. In particular, T-lymphocytes are recognized as important players in its pathogenesis. Despite substantial experimental efforts, the molecular mechanisms underlying the nature of T-cell activation contributing to an onset of hypertension or disease perpetuation are still elusive. Amongst other cell types, lymphocytes express distinct profiles of GPCRs for sphingosine-1-phosphate (S1P) – a bioactive phospholipid that is involved in many critical cell processes and most importantly majorly regulates T-cell development, lymphocyte recirculation, tissue-homing patterns and chemotactic responses. Recent findings have revealed a key role for S1P chemotaxis and T-cell mobilization for... (More)
The immune system plays a considerable role in hypertension. In particular, T-lymphocytes are recognized as important players in its pathogenesis. Despite substantial experimental efforts, the molecular mechanisms underlying the nature of T-cell activation contributing to an onset of hypertension or disease perpetuation are still elusive. Amongst other cell types, lymphocytes express distinct profiles of GPCRs for sphingosine-1-phosphate (S1P) – a bioactive phospholipid that is involved in many critical cell processes and most importantly majorly regulates T-cell development, lymphocyte recirculation, tissue-homing patterns and chemotactic responses. Recent findings have revealed a key role for S1P chemotaxis and T-cell mobilization for the onset of experimental hypertension, and elevated circulating S1P levels have been linked to several inflammation-associated diseases including hypertension in patients. In this article, we review the recent progress towards understanding how S1P and its receptors regulate immune cell trafficking and function and its potential relevance for the pathophysiology of hypertension. Linked Articles: This article is part of a themed section on Immune Targets in Hypertension. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Pharmacology
volume
176
issue
12
pages
1989 - 2001
publisher
Wiley
external identifiers
  • scopus:85050461119
  • pmid:29856066
ISSN
1476-5381
DOI
10.1111/bph.14381
language
English
LU publication?
yes
id
a47c4be0-4e87-4a17-8f2d-177c6b1e9d32
date added to LUP
2018-06-04 12:52:32
date last changed
2022-05-12 00:19:25
@article{a47c4be0-4e87-4a17-8f2d-177c6b1e9d32,
  abstract     = {{The immune system plays a considerable role in hypertension. In particular, T-lymphocytes are recognized as important players in its pathogenesis. Despite substantial experimental efforts, the molecular mechanisms underlying the nature of T-cell activation contributing to an onset of hypertension or disease perpetuation are still elusive. Amongst other cell types, lymphocytes express distinct profiles of GPCRs for sphingosine-1-phosphate (S1P) – a bioactive phospholipid that is involved in many critical cell processes and most importantly majorly regulates T-cell development, lymphocyte recirculation, tissue-homing patterns and chemotactic responses. Recent findings have revealed a key role for S1P chemotaxis and T-cell mobilization for the onset of experimental hypertension, and elevated circulating S1P levels have been linked to several inflammation-associated diseases including hypertension in patients. In this article, we review the recent progress towards understanding how S1P and its receptors regulate immune cell trafficking and function and its potential relevance for the pathophysiology of hypertension. Linked Articles: This article is part of a themed section on Immune Targets in Hypertension.}},
  author       = {{Don-Doncow, Nicholas and Zhang, Yun and Matuskova, Hana and Meissner, Anja}},
  issn         = {{1476-5381}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{1989--2001}},
  publisher    = {{Wiley}},
  series       = {{British Journal of Pharmacology}},
  title        = {{The emerging alliance of sphingosine-1-phosphate signaling and immune cells: from basic mechanisms to implications in hypertension.}},
  url          = {{http://dx.doi.org/10.1111/bph.14381}},
  doi          = {{10.1111/bph.14381}},
  volume       = {{176}},
  year         = {{2019}},
}