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Mitogen- and stress-activated protein kinase 1 is required for specific signaling responses in dopamine-denervated mouse striatum, but is not necessary for l-DOPA-induced dyskinesia

Alcacer, Cristina LU ; Charbonnier-Beaupel, Fanny ; Corvol, Jean-Christophe ; Girault, Jean-Antoine and Hervé, Denis (2014) In Neuroscience Letters 583. p.76-80
Abstract

In advanced Parkinson's disease, l-DOPA treatment causes the appearance of abnormal involuntary movements or l-DOPA-induced dyskinesia (LID). LID results in part from l-DOPA-induced activation of extracellular signal-regulated kinase (ERK) in the dopamine-denervated striatum. Activated ERK triggers nuclear responses, including phosphorylation of mitogen- and stress-activated protein kinase 1 (MSK1) and histone H3, and transcription of genes such as FosB. To determine the role of MSK1, wild type and MSK1 knockout mice with unilateral 6-hydroxydopamine lesion in the dorsolateral striatum were chronically treated with l-DOPA. The absence of MSK1 had no effect on the lesion or l-DOPA-induced ERK activation, but reduced l-DOPA-induced... (More)

In advanced Parkinson's disease, l-DOPA treatment causes the appearance of abnormal involuntary movements or l-DOPA-induced dyskinesia (LID). LID results in part from l-DOPA-induced activation of extracellular signal-regulated kinase (ERK) in the dopamine-denervated striatum. Activated ERK triggers nuclear responses, including phosphorylation of mitogen- and stress-activated protein kinase 1 (MSK1) and histone H3, and transcription of genes such as FosB. To determine the role of MSK1, wild type and MSK1 knockout mice with unilateral 6-hydroxydopamine lesion in the dorsolateral striatum were chronically treated with l-DOPA. The absence of MSK1 had no effect on the lesion or l-DOPA-induced ERK activation, but reduced l-DOPA-induced phosphorylation of histone H3 and FosB accumulation in the dopamine-denervated striatum. MSK1 deficiency also prevented the increase in Gαolf, the stimulatory α subunit of G protein coupling striatal dopamine D1 receptor to adenylyl cyclase. However, the intensity of LID was similar in MSK1-deficient and wild type mice. In conclusion, l-DOPA-induced activation of MSK1 contributes to histone H3 phosphorylation, induction of FosB, and Gαolf up-regulation but appears not to be necessary for the development of LID.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
6-OHDA, Extracellular signal-regulated kinase, L-DOPA-induced dyskinesia, Parkinson's disease, Signaling
in
Neuroscience Letters
volume
583
pages
5 pages
publisher
Elsevier
external identifiers
  • pmid:25233866
  • scopus:84907778920
ISSN
0304-3940
DOI
10.1016/j.neulet.2014.09.018
language
English
LU publication?
no
id
a6018d3c-0cc4-4c0f-a64b-9ad04e86288d
date added to LUP
2017-02-14 16:13:10
date last changed
2024-01-13 13:59:45
@article{a6018d3c-0cc4-4c0f-a64b-9ad04e86288d,
  abstract     = {{<p>In advanced Parkinson's disease, l-DOPA treatment causes the appearance of abnormal involuntary movements or l-DOPA-induced dyskinesia (LID). LID results in part from l-DOPA-induced activation of extracellular signal-regulated kinase (ERK) in the dopamine-denervated striatum. Activated ERK triggers nuclear responses, including phosphorylation of mitogen- and stress-activated protein kinase 1 (MSK1) and histone H3, and transcription of genes such as FosB. To determine the role of MSK1, wild type and MSK1 knockout mice with unilateral 6-hydroxydopamine lesion in the dorsolateral striatum were chronically treated with l-DOPA. The absence of MSK1 had no effect on the lesion or l-DOPA-induced ERK activation, but reduced l-DOPA-induced phosphorylation of histone H3 and FosB accumulation in the dopamine-denervated striatum. MSK1 deficiency also prevented the increase in Gαolf, the stimulatory α subunit of G protein coupling striatal dopamine D1 receptor to adenylyl cyclase. However, the intensity of LID was similar in MSK1-deficient and wild type mice. In conclusion, l-DOPA-induced activation of MSK1 contributes to histone H3 phosphorylation, induction of FosB, and Gαolf up-regulation but appears not to be necessary for the development of LID.</p>}},
  author       = {{Alcacer, Cristina and Charbonnier-Beaupel, Fanny and Corvol, Jean-Christophe and Girault, Jean-Antoine and Hervé, Denis}},
  issn         = {{0304-3940}},
  keywords     = {{6-OHDA; Extracellular signal-regulated kinase; L-DOPA-induced dyskinesia; Parkinson's disease; Signaling}},
  language     = {{eng}},
  month        = {{11}},
  pages        = {{76--80}},
  publisher    = {{Elsevier}},
  series       = {{Neuroscience Letters}},
  title        = {{Mitogen- and stress-activated protein kinase 1 is required for specific signaling responses in dopamine-denervated mouse striatum, but is not necessary for l-DOPA-induced dyskinesia}},
  url          = {{http://dx.doi.org/10.1016/j.neulet.2014.09.018}},
  doi          = {{10.1016/j.neulet.2014.09.018}},
  volume       = {{583}},
  year         = {{2014}},
}