Elevated circulating effector memory T cells but similar levels of regulatory T cells in patients with type 2 diabetes mellitus and cardiovascular disease
(2019) In Diabetes and Vascular Disease Research 16(3). p.270-280- Abstract
Type 2 diabetes mellitus is associated with an elevated risk of cardiovascular disease, but the mechanism through which diabetes contributes to cardiovascular disease development remains incompletely understood. In this study, we compared the association of circulating regulatory T cells, naïve T cells, effector memory T cells or central memory T cells with cardiovascular disease in patients with and without type 2 diabetes mellitus. Percentage of circulating T cell subsets was analysed by flow cytometry in type 2 diabetes mellitus subjects with and without prevalent cardiovascular disease as well as in non-diabetic subjects with and without prevalent cardiovascular disease from the Malmö SUMMIT cohort. Subjects with type 2 diabetes... (More)
Type 2 diabetes mellitus is associated with an elevated risk of cardiovascular disease, but the mechanism through which diabetes contributes to cardiovascular disease development remains incompletely understood. In this study, we compared the association of circulating regulatory T cells, naïve T cells, effector memory T cells or central memory T cells with cardiovascular disease in patients with and without type 2 diabetes mellitus. Percentage of circulating T cell subsets was analysed by flow cytometry in type 2 diabetes mellitus subjects with and without prevalent cardiovascular disease as well as in non-diabetic subjects with and without prevalent cardiovascular disease from the Malmö SUMMIT cohort. Subjects with type 2 diabetes mellitus had elevated percentages of effector memory T cells (CD4+CD45RO+CD62L–; 21.8% ± 11.2% vs 17.0% ± 9.2% in non-type 2 diabetes mellitus, p < 0.01) and central memory T cells (CD4+CD45RO+CD62L+; 38.0% ± 10.7% vs 36.0% ± 9.5% in non-type 2 diabetes mellitus, p < 0.01). In contrast, the frequency of naïve T cells was reduced (CD4+CD45RO–CD62L+, 35.0% ± 16.5% vs 42.9% ± 14.4% in non-type 2 diabetes mellitus, p < 0.001). The proportion of effector memory T cells was increased in type 2 diabetes mellitus subjects with cardiovascular disease as compared to those without (26.4% ± 11.5% vs 18.4% ± 10.2%, p < 0.05), while no difference in regulatory T cells was observed between these two patient groups. This study identifies effector memory T cells as a potential cellular biomarker for cardiovascular disease among subjects with type 2 diabetes mellitus, suggesting a state of exacerbated immune activation in type 2 diabetes mellitus patients with cardiovascular disease.
(Less)
- author
- Rattik, Sara LU ; Engelbertsen, Daniel LU ; Wigren, Maria LU ; Ljungcrantz, Irena LU ; Östling, Gerd LU ; Persson, Margaretha LU ; Nordin Fredrikson, Gunilla LU ; Bengtsson, Eva LU ; Nilsson, Jan LU and Björkbacka, Harry LU
- organization
-
- Cardiovascular Research - Immunity and Atherosclerosis (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- Internal Medicine - Epidemiology (research group)
- Cardiovascular Research - Matrix and Inflammation in Atherosclerosis (research group)
- Cardiovascular Research - Cellular Metabolism and Inflammation (research group)
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- adaptive immunity, cardiovascular disease, memory T cells, regulatory T cells, Type 2 diabetes
- in
- Diabetes and Vascular Disease Research
- volume
- 16
- issue
- 3
- pages
- 270 - 280
- publisher
- SAGE Publications
- external identifiers
-
- scopus:85059016898
- pmid:30574794
- ISSN
- 1479-1641
- DOI
- 10.1177/1479164118817942
- language
- English
- LU publication?
- yes
- id
- aae7cd27-264f-4a59-980a-a8aee57cd754
- date added to LUP
- 2019-01-07 14:06:09
- date last changed
- 2024-09-17 09:45:17
@article{aae7cd27-264f-4a59-980a-a8aee57cd754, abstract = {{<p>Type 2 diabetes mellitus is associated with an elevated risk of cardiovascular disease, but the mechanism through which diabetes contributes to cardiovascular disease development remains incompletely understood. In this study, we compared the association of circulating regulatory T cells, naïve T cells, effector memory T cells or central memory T cells with cardiovascular disease in patients with and without type 2 diabetes mellitus. Percentage of circulating T cell subsets was analysed by flow cytometry in type 2 diabetes mellitus subjects with and without prevalent cardiovascular disease as well as in non-diabetic subjects with and without prevalent cardiovascular disease from the Malmö SUMMIT cohort. Subjects with type 2 diabetes mellitus had elevated percentages of effector memory T cells (CD4<sup>+</sup>CD45RO<sup>+</sup>CD62L<sup>–</sup>; 21.8% ± 11.2% vs 17.0% ± 9.2% in non-type 2 diabetes mellitus, p < 0.01) and central memory T cells (CD4<sup>+</sup>CD45RO<sup>+</sup>CD62L<sup>+</sup>; 38.0% ± 10.7% vs 36.0% ± 9.5% in non-type 2 diabetes mellitus, p < 0.01). In contrast, the frequency of naïve T cells was reduced (CD4<sup>+</sup>CD45RO<sup>–</sup>CD62L<sup>+</sup>, 35.0% ± 16.5% vs 42.9% ± 14.4% in non-type 2 diabetes mellitus, p < 0.001). The proportion of effector memory T cells was increased in type 2 diabetes mellitus subjects with cardiovascular disease as compared to those without (26.4% ± 11.5% vs 18.4% ± 10.2%, p < 0.05), while no difference in regulatory T cells was observed between these two patient groups. This study identifies effector memory T cells as a potential cellular biomarker for cardiovascular disease among subjects with type 2 diabetes mellitus, suggesting a state of exacerbated immune activation in type 2 diabetes mellitus patients with cardiovascular disease.</p>}}, author = {{Rattik, Sara and Engelbertsen, Daniel and Wigren, Maria and Ljungcrantz, Irena and Östling, Gerd and Persson, Margaretha and Nordin Fredrikson, Gunilla and Bengtsson, Eva and Nilsson, Jan and Björkbacka, Harry}}, issn = {{1479-1641}}, keywords = {{adaptive immunity; cardiovascular disease; memory T cells; regulatory T cells; Type 2 diabetes}}, language = {{eng}}, number = {{3}}, pages = {{270--280}}, publisher = {{SAGE Publications}}, series = {{Diabetes and Vascular Disease Research}}, title = {{Elevated circulating effector memory T cells but similar levels of regulatory T cells in patients with type 2 diabetes mellitus and cardiovascular disease}}, url = {{http://dx.doi.org/10.1177/1479164118817942}}, doi = {{10.1177/1479164118817942}}, volume = {{16}}, year = {{2019}}, }