Repeat procedures for recurrent colorectal liver metastases : Analysis of long-term liver regeneration and outcome
(2019) In Cancer Management and Research 11. p.2617-2622- Abstract
Background and aim: Repeat hepatectomy is increasingly performed for the management of recurrent colorectal liver metastases (CRLM). The aim of this study was to evaluate longterm functional liver volume (FLV) after a second hepatic procedure and to measure survival outcome. Methods: In this retrospective cohort study, patients treated for recurrent CRLM in the years 2005-2015 at two liver centers were included. Total FLV was calculated before the first procedure and before and after the second procedure. Overall survival was calculated. Results: Eighty-two patients were identified. The median follow-up was 53 (40-71) months from the first procedure. The median interval between first and second procedure was 13 (8-22) months. The... (More)
Background and aim: Repeat hepatectomy is increasingly performed for the management of recurrent colorectal liver metastases (CRLM). The aim of this study was to evaluate longterm functional liver volume (FLV) after a second hepatic procedure and to measure survival outcome. Methods: In this retrospective cohort study, patients treated for recurrent CRLM in the years 2005-2015 at two liver centers were included. Total FLV was calculated before the first procedure and before and after the second procedure. Overall survival was calculated. Results: Eighty-two patients were identified. The median follow-up was 53 (40-71) months from the first procedure. The median interval between first and second procedure was 13 (8-22) months. The initial FLV was 1584 (1313-1927) mL. The FLV was 1438 (1204-1896) mL after the first procedure and 1470 (1172-1699) mL after the second procedure (P<0.001). After the second procedure, a total of ten patients (12%) had a residual liver volume of less than 75% of the initial liver volume. The 5-year overall survival was 37 (26-54)% after the second procedure. Conclusion: Small changes in FLV were found after two hepatic procedures but with considerable inter-individual variation. Patients selected for a repeated hepatic procedure for recurrent CRLM had an acceptable survival.
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- author
- Valdimarsson, Valentinus T. LU ; Hellberg, Katarina ; Brismar, Torkel B. ; Sparrelid, Ernesto and Sturesson, Christian LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Colorectal cancer, Liver metastases, Liver regeneration, Postoperative outcomes, Repeat hepatectomy
- in
- Cancer Management and Research
- volume
- 11
- pages
- 6 pages
- publisher
- Dove Medical Press Ltd.
- external identifiers
-
- pmid:31118767
- scopus:85065066080
- ISSN
- 1179-1322
- DOI
- 10.2147/CMAR.S191653
- language
- English
- LU publication?
- yes
- id
- ae255fe8-f434-4578-8547-e39c0c64cc3c
- date added to LUP
- 2019-05-17 13:18:14
- date last changed
- 2024-09-17 21:16:08
@article{ae255fe8-f434-4578-8547-e39c0c64cc3c, abstract = {{<p>Background and aim: Repeat hepatectomy is increasingly performed for the management of recurrent colorectal liver metastases (CRLM). The aim of this study was to evaluate longterm functional liver volume (FLV) after a second hepatic procedure and to measure survival outcome. Methods: In this retrospective cohort study, patients treated for recurrent CRLM in the years 2005-2015 at two liver centers were included. Total FLV was calculated before the first procedure and before and after the second procedure. Overall survival was calculated. Results: Eighty-two patients were identified. The median follow-up was 53 (40-71) months from the first procedure. The median interval between first and second procedure was 13 (8-22) months. The initial FLV was 1584 (1313-1927) mL. The FLV was 1438 (1204-1896) mL after the first procedure and 1470 (1172-1699) mL after the second procedure (P<0.001). After the second procedure, a total of ten patients (12%) had a residual liver volume of less than 75% of the initial liver volume. The 5-year overall survival was 37 (26-54)% after the second procedure. Conclusion: Small changes in FLV were found after two hepatic procedures but with considerable inter-individual variation. Patients selected for a repeated hepatic procedure for recurrent CRLM had an acceptable survival.</p>}}, author = {{Valdimarsson, Valentinus T. and Hellberg, Katarina and Brismar, Torkel B. and Sparrelid, Ernesto and Sturesson, Christian}}, issn = {{1179-1322}}, keywords = {{Colorectal cancer; Liver metastases; Liver regeneration; Postoperative outcomes; Repeat hepatectomy}}, language = {{eng}}, pages = {{2617--2622}}, publisher = {{Dove Medical Press Ltd.}}, series = {{Cancer Management and Research}}, title = {{Repeat procedures for recurrent colorectal liver metastases : Analysis of long-term liver regeneration and outcome}}, url = {{http://dx.doi.org/10.2147/CMAR.S191653}}, doi = {{10.2147/CMAR.S191653}}, volume = {{11}}, year = {{2019}}, }