Atrial fibrosis : An obligatory component of arrhythmia mechanisms in atrial fibrillation?
(2017) In Journal of Geriatric Cardiology 14(4). p.233-237- Abstract
Atrial fibrosis is common in atrial fibrillation (AF). Experimental studies have provided convincing evidence that fibrotic transformation of atrial myocardium results in deterioration of atrial conduction, increasing anisotropy of impulse propagation and building of boundaries that promote re-entry in the atrial walls that maybe directly relevant for the mechanisms responsible for maintaining AF. Whether or not fibrosis is a result of structural remodelling caused by persistent AF or a manifestation of occult myocardial process that leads to development of arrhythmia is less clear. Human data indicate the presence of association between persistency of AF and the extent of structural changes in atrial myocardium. The role atrial... (More)
Atrial fibrosis is common in atrial fibrillation (AF). Experimental studies have provided convincing evidence that fibrotic transformation of atrial myocardium results in deterioration of atrial conduction, increasing anisotropy of impulse propagation and building of boundaries that promote re-entry in the atrial walls that maybe directly relevant for the mechanisms responsible for maintaining AF. Whether or not fibrosis is a result of structural remodelling caused by persistent AF or a manifestation of occult myocardial process that leads to development of arrhythmia is less clear. Human data indicate the presence of association between persistency of AF and the extent of structural changes in atrial myocardium. The role atrial fibrosis plays in the mechanisms of AF, however, may differ between patients with structurally normal hearts, such as lone AF, and those with advanced cardiovascular comorbidities.
(Less)
- author
- Platonov, Pyotr G. LU
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Atrial fibrillation, Fibrosis, Remodeling
- in
- Journal of Geriatric Cardiology
- volume
- 14
- issue
- 4
- pages
- 5 pages
- publisher
- Science Press
- external identifiers
-
- pmid:28663760
- wos:000413836500002
- scopus:85020860566
- ISSN
- 1671-5411
- DOI
- 10.11909/j.issn.1671-5411.2017.04.008
- language
- English
- LU publication?
- yes
- id
- b1895d92-a112-4d90-8b58-5bbb12f510aa
- date added to LUP
- 2017-08-22 11:41:02
- date last changed
- 2024-04-14 16:09:41
@article{b1895d92-a112-4d90-8b58-5bbb12f510aa,
abstract = {{<p>Atrial fibrosis is common in atrial fibrillation (AF). Experimental studies have provided convincing evidence that fibrotic transformation of atrial myocardium results in deterioration of atrial conduction, increasing anisotropy of impulse propagation and building of boundaries that promote re-entry in the atrial walls that maybe directly relevant for the mechanisms responsible for maintaining AF. Whether or not fibrosis is a result of structural remodelling caused by persistent AF or a manifestation of occult myocardial process that leads to development of arrhythmia is less clear. Human data indicate the presence of association between persistency of AF and the extent of structural changes in atrial myocardium. The role atrial fibrosis plays in the mechanisms of AF, however, may differ between patients with structurally normal hearts, such as lone AF, and those with advanced cardiovascular comorbidities.</p>}},
author = {{Platonov, Pyotr G.}},
issn = {{1671-5411}},
keywords = {{Atrial fibrillation; Fibrosis; Remodeling}},
language = {{eng}},
number = {{4}},
pages = {{233--237}},
publisher = {{Science Press}},
series = {{Journal of Geriatric Cardiology}},
title = {{Atrial fibrosis : An obligatory component of arrhythmia mechanisms in atrial fibrillation?}},
url = {{http://dx.doi.org/10.11909/j.issn.1671-5411.2017.04.008}},
doi = {{10.11909/j.issn.1671-5411.2017.04.008}},
volume = {{14}},
year = {{2017}},
}