The immune modulator Linomide prevents neuronal death in injured peripheral nerves of the mouse
(1998) In NeuroReport 9(7). p.1337-1341- Abstract
Neuronal death after injury or disease could result from imbalanced cytokine expression. Linomide (LS-2616, quinoline-3-carboxamide), a synthetic immunomodulator with effects on cytokine production, suppresses autoimmune diseases of the nervous system. Here adult mice were pre-treated with 200 mg/kg/day of Linomide for 9 days, after which the sciatic nerves were crushed. After another 10 days of Linomide treatment the dorsal root ganglia were dissected out and stained for apoptosis, either immediately or after 2 days in culture, which increases cell death. Superior cervical ganglia were also cultured for 2 days. The Linomide pretreatment profoundly reduced (~60- 80%) the injury-induced apoptotic death of neurons and satellite cells in... (More)
Neuronal death after injury or disease could result from imbalanced cytokine expression. Linomide (LS-2616, quinoline-3-carboxamide), a synthetic immunomodulator with effects on cytokine production, suppresses autoimmune diseases of the nervous system. Here adult mice were pre-treated with 200 mg/kg/day of Linomide for 9 days, after which the sciatic nerves were crushed. After another 10 days of Linomide treatment the dorsal root ganglia were dissected out and stained for apoptosis, either immediately or after 2 days in culture, which increases cell death. Superior cervical ganglia were also cultured for 2 days. The Linomide pretreatment profoundly reduced (~60- 80%) the injury-induced apoptotic death of neurons and satellite cells in both systems. The results suggest that modulation of the inflammatory cytokine cascade is a promising road to nerve cell rescue.
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- author
- Ekström, Per LU ; Hedlund, Gunnar ; Karlsson, Jenny and Andersson, Gunnar
- organization
- publishing date
- 1998-05-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Apoptosis, Cytokines, Immunomodulation, Macrophages, Nerve regeneration, Neuronal death, Neuronal survival, Peripheral nerves
- in
- NeuroReport
- volume
- 9
- issue
- 7
- pages
- 5 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:9631425
- scopus:0032507669
- ISSN
- 0959-4965
- language
- English
- LU publication?
- yes
- id
- b2f15337-4341-4f7b-93b3-dce1376d78bd
- date added to LUP
- 2016-12-07 14:46:14
- date last changed
- 2024-01-04 18:22:00
@article{b2f15337-4341-4f7b-93b3-dce1376d78bd,
abstract = {{<p>Neuronal death after injury or disease could result from imbalanced cytokine expression. Linomide (LS-2616, quinoline-3-carboxamide), a synthetic immunomodulator with effects on cytokine production, suppresses autoimmune diseases of the nervous system. Here adult mice were pre-treated with 200 mg/kg/day of Linomide for 9 days, after which the sciatic nerves were crushed. After another 10 days of Linomide treatment the dorsal root ganglia were dissected out and stained for apoptosis, either immediately or after 2 days in culture, which increases cell death. Superior cervical ganglia were also cultured for 2 days. The Linomide pretreatment profoundly reduced (~60- 80%) the injury-induced apoptotic death of neurons and satellite cells in both systems. The results suggest that modulation of the inflammatory cytokine cascade is a promising road to nerve cell rescue.</p>}},
author = {{Ekström, Per and Hedlund, Gunnar and Karlsson, Jenny and Andersson, Gunnar}},
issn = {{0959-4965}},
keywords = {{Apoptosis; Cytokines; Immunomodulation; Macrophages; Nerve regeneration; Neuronal death; Neuronal survival; Peripheral nerves}},
language = {{eng}},
month = {{05}},
number = {{7}},
pages = {{1337--1341}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{NeuroReport}},
title = {{The immune modulator Linomide prevents neuronal death in injured peripheral nerves of the mouse}},
volume = {{9}},
year = {{1998}},
}