Antileishmanial metabolites from Lantana balansae
(2016) In Brazilian Journal of Pharmacognosy 26(2). p.180-183- Abstract
Eleven compounds, 12-oxo-phytodienoic acid (1), persicogenin (2), eriodictyol 3ʹ4ʹ,7-trimethyl ether (3), phytol (4), spathulenol (5), 4-hydroxycinnamic acid (6), onopordin (7), 5,8,4ʹ-trihydroxy-7,3ʹ-dimethoxyflavone (8), quercetin (9), jaceosidin (10), and 8-hydroxyluteolin (11), were isolated from an ethanol extract of Lantana balansae Briq., Verbenaceae, that was found to possess antileishmanial activ-ity. The structures of the compounds were determined by NMR spectroscopy and HR mass spectrometry, and 1, 2, 3, 7, 8 and 9 were investigated for antiprotozoal activity toward promastigotes of Leishmania amazonensis and Leishmania braziliensis. Compound 1 was shown to be the most potent, with the IC50 values 2.0µM toward L.... (More)
Eleven compounds, 12-oxo-phytodienoic acid (1), persicogenin (2), eriodictyol 3ʹ4ʹ,7-trimethyl ether (3), phytol (4), spathulenol (5), 4-hydroxycinnamic acid (6), onopordin (7), 5,8,4ʹ-trihydroxy-7,3ʹ-dimethoxyflavone (8), quercetin (9), jaceosidin (10), and 8-hydroxyluteolin (11), were isolated from an ethanol extract of Lantana balansae Briq., Verbenaceae, that was found to possess antileishmanial activ-ity. The structures of the compounds were determined by NMR spectroscopy and HR mass spectrometry, and 1, 2, 3, 7, 8 and 9 were investigated for antiprotozoal activity toward promastigotes of Leishmania amazonensis and Leishmania braziliensis. Compound 1 was shown to be the most potent, with the IC50 values 2.0µM toward L. amazonensis and 0.68µM toward L. braziliensis, although less potent than the positive control Amphotericin B. All compounds have been reported previously, but this is the first report of the isolation of a cyclopentenone fatty acid (1) and flavanones (2 and 3) from a Lantana species.
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- author
- Maldonado, Eliana M. LU ; Salamanca, Efrain ; Giménez, Alberto and Sterner, Olov LU
- organization
- publishing date
- 2016-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 12-oxo-phytodienoic acid, Flavonoids, L. braziliensis, Lantana balansae, Leishmania amazonensis
- in
- Brazilian Journal of Pharmacognosy
- volume
- 26
- issue
- 2
- pages
- 4 pages
- publisher
- Sociedade Brasileira de Farmacognosia
- external identifiers
-
- scopus:84963727382
- ISSN
- 0102-695X
- DOI
- 10.1016/j.bjp.2015.11.007
- language
- English
- LU publication?
- yes
- id
- b4ca468c-b458-4948-9d5c-27ba4b82fe43
- date added to LUP
- 2016-09-22 08:12:57
- date last changed
- 2022-04-08 23:20:29
@article{b4ca468c-b458-4948-9d5c-27ba4b82fe43, abstract = {{<p>Eleven compounds, 12-oxo-phytodienoic acid (1), persicogenin (2), eriodictyol 3ʹ4ʹ,7-trimethyl ether (3), phytol (4), spathulenol (5), 4-hydroxycinnamic acid (6), onopordin (7), 5,8,4ʹ-trihydroxy-7,3ʹ-dimethoxyflavone (8), quercetin (9), jaceosidin (10), and 8-hydroxyluteolin (11), were isolated from an ethanol extract of Lantana balansae Briq., Verbenaceae, that was found to possess antileishmanial activ-ity. The structures of the compounds were determined by NMR spectroscopy and HR mass spectrometry, and 1, 2, 3, 7, 8 and 9 were investigated for antiprotozoal activity toward promastigotes of Leishmania amazonensis and Leishmania braziliensis. Compound 1 was shown to be the most potent, with the IC<sub>50</sub> values 2.0µM toward L. amazonensis and 0.68µM toward L. braziliensis, although less potent than the positive control Amphotericin B. All compounds have been reported previously, but this is the first report of the isolation of a cyclopentenone fatty acid (1) and flavanones (2 and 3) from a Lantana species.</p>}}, author = {{Maldonado, Eliana M. and Salamanca, Efrain and Giménez, Alberto and Sterner, Olov}}, issn = {{0102-695X}}, keywords = {{12-oxo-phytodienoic acid; Flavonoids; L. braziliensis; Lantana balansae; Leishmania amazonensis}}, language = {{eng}}, month = {{01}}, number = {{2}}, pages = {{180--183}}, publisher = {{Sociedade Brasileira de Farmacognosia}}, series = {{Brazilian Journal of Pharmacognosy}}, title = {{Antileishmanial metabolites from Lantana balansae}}, url = {{http://dx.doi.org/10.1016/j.bjp.2015.11.007}}, doi = {{10.1016/j.bjp.2015.11.007}}, volume = {{26}}, year = {{2016}}, }