Structural insights into eukaryotic aquaporin regulation
(2010) In FEBS Letters 584(12). p.2580-2588- Abstract
Aquaporin-mediated water transport across cellular membranes is an ancient, ubiquitous mechanism within cell biology. This family of integral membrane proteins includes both water selective pores (aquaporins) and transport facilitators of other small molecules such as glycerol and urea (aquaglyceroporins). Eukaryotic aquaporins are frequently regulated post-translationally by gating, whereby the rate of flux through the channel is controlled, or by trafficking, whereby aquaporins are shuttled from intracellular storage sites to the plasma membrane. A number of high-resolution X-ray structures of eukaryotic aquaporins have recently been reported and the new structural insights into gating and trafficking that emerged from these studies... (More)
Aquaporin-mediated water transport across cellular membranes is an ancient, ubiquitous mechanism within cell biology. This family of integral membrane proteins includes both water selective pores (aquaporins) and transport facilitators of other small molecules such as glycerol and urea (aquaglyceroporins). Eukaryotic aquaporins are frequently regulated post-translationally by gating, whereby the rate of flux through the channel is controlled, or by trafficking, whereby aquaporins are shuttled from intracellular storage sites to the plasma membrane. A number of high-resolution X-ray structures of eukaryotic aquaporins have recently been reported and the new structural insights into gating and trafficking that emerged from these studies are described. Basic structural themes reoccur, illustrating how the problem of regulation in diverse biological contexts builds upon a limited set of possible solutions.
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- author
- Törnroth-Horsefield, Susanna LU ; Hedfalk, Kristina ; Fischer, Gerhard ; Lindkvist-Petersson, Karin LU and Neutze, Richard
- publishing date
- 2010-06
- type
- Contribution to journal
- publication status
- published
- keywords
- Aquaporin, Membrane protein structural biology, X-ray diffraction
- in
- FEBS Letters
- volume
- 584
- issue
- 12
- pages
- 9 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:20416297
- scopus:77953578957
- ISSN
- 0014-5793
- DOI
- 10.1016/j.febslet.2010.04.037
- language
- English
- LU publication?
- no
- id
- bc37d4d9-4ff3-4257-9b81-6eee84f16532
- date added to LUP
- 2017-02-14 16:27:31
- date last changed
- 2024-09-16 18:28:39
@article{bc37d4d9-4ff3-4257-9b81-6eee84f16532, abstract = {{<p>Aquaporin-mediated water transport across cellular membranes is an ancient, ubiquitous mechanism within cell biology. This family of integral membrane proteins includes both water selective pores (aquaporins) and transport facilitators of other small molecules such as glycerol and urea (aquaglyceroporins). Eukaryotic aquaporins are frequently regulated post-translationally by gating, whereby the rate of flux through the channel is controlled, or by trafficking, whereby aquaporins are shuttled from intracellular storage sites to the plasma membrane. A number of high-resolution X-ray structures of eukaryotic aquaporins have recently been reported and the new structural insights into gating and trafficking that emerged from these studies are described. Basic structural themes reoccur, illustrating how the problem of regulation in diverse biological contexts builds upon a limited set of possible solutions.</p>}}, author = {{Törnroth-Horsefield, Susanna and Hedfalk, Kristina and Fischer, Gerhard and Lindkvist-Petersson, Karin and Neutze, Richard}}, issn = {{0014-5793}}, keywords = {{Aquaporin; Membrane protein structural biology; X-ray diffraction}}, language = {{eng}}, number = {{12}}, pages = {{2580--2588}}, publisher = {{Wiley-Blackwell}}, series = {{FEBS Letters}}, title = {{Structural insights into eukaryotic aquaporin regulation}}, url = {{http://dx.doi.org/10.1016/j.febslet.2010.04.037}}, doi = {{10.1016/j.febslet.2010.04.037}}, volume = {{584}}, year = {{2010}}, }