Risks for familial and contralateral breast cancer interact multiplicatively and cause a high risk
Hemminki, Kari LU ; Ji, Jianguang LU
and Försti, Asta
LU
(2007)
In Cancer Research
67(3).
p.70-868
- Abstract
The reasons for the high risk of contralateral breast cancer are not understood, although polygenic mechanisms have been suggested to be involved. The nationwide Swedish Family-Cancer Database was used to examine the interaction of the risks for contralateral and familial cancer. Relative risks were separately determined for contralateral and familial breast cancers, and these were tested for additive and multiplicative interactions. The Database contained information on 102,176 first breast cancers. Familial risk for breast cancer was 1.76 and the risk for contralateral breast cancer was 3.40, or 5.80 when extrapolated to two breasts. When women had a family history, the risk for contralateral breast cancer was remarkably high, 5.48,... (More)
The reasons for the high risk of contralateral breast cancer are not understood, although polygenic mechanisms have been suggested to be involved. The nationwide Swedish Family-Cancer Database was used to examine the interaction of the risks for contralateral and familial cancer. Relative risks were separately determined for contralateral and familial breast cancers, and these were tested for additive and multiplicative interactions. The Database contained information on 102,176 first breast cancers. Familial risk for breast cancer was 1.76 and the risk for contralateral breast cancer was 3.40, or 5.80 when extrapolated to two breasts. When women had a family history, the risk for contralateral breast cancer was remarkably high, 5.48, or 9.96 when the risk was extrapolated to two breasts, almost identical with 10.21, which was predicted by the multiplicative model. Although the data do not rule out polygenic mechanisms, they suggest that epigenetic imprinting events may be involved for the contralateral breast cancer.
(Less)
- author
- Hemminki, Kari
LU
; Ji, Jianguang
LU
and Försti, Asta
LU
- publishing date
- 2007-02-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Breast Neoplasms/epidemiology, Family Health, Female, Genetic Predisposition to Disease, Humans, Neoplasms, Second Primary/epidemiology, Risk Factors, Sweden/epidemiology
- in
- Cancer Research
- volume
- 67
- issue
- 3
- pages
- 3 pages
- publisher
- American Association for Cancer Research Inc.
- external identifiers
-
- pmid:17283115
- scopus:33847054432
- ISSN
- 0008-5472
- DOI
- 10.1158/0008-5472.CAN-06-3854
- language
- English
- LU publication?
- no
- id
- bfea52b7-ee85-4e7d-8d84-f8e0ed00f2c9
- date added to LUP
- 2019-01-30 10:51:27
- date last changed
- 2024-04-15 21:52:55
@article{bfea52b7-ee85-4e7d-8d84-f8e0ed00f2c9,
abstract = {{<p>The reasons for the high risk of contralateral breast cancer are not understood, although polygenic mechanisms have been suggested to be involved. The nationwide Swedish Family-Cancer Database was used to examine the interaction of the risks for contralateral and familial cancer. Relative risks were separately determined for contralateral and familial breast cancers, and these were tested for additive and multiplicative interactions. The Database contained information on 102,176 first breast cancers. Familial risk for breast cancer was 1.76 and the risk for contralateral breast cancer was 3.40, or 5.80 when extrapolated to two breasts. When women had a family history, the risk for contralateral breast cancer was remarkably high, 5.48, or 9.96 when the risk was extrapolated to two breasts, almost identical with 10.21, which was predicted by the multiplicative model. Although the data do not rule out polygenic mechanisms, they suggest that epigenetic imprinting events may be involved for the contralateral breast cancer.</p>}},
author = {{Hemminki, Kari and Ji, Jianguang and Försti, Asta}},
issn = {{0008-5472}},
keywords = {{Breast Neoplasms/epidemiology; Family Health; Female; Genetic Predisposition to Disease; Humans; Neoplasms, Second Primary/epidemiology; Risk Factors; Sweden/epidemiology}},
language = {{eng}},
month = {{02}},
number = {{3}},
pages = {{70--868}},
publisher = {{American Association for Cancer Research Inc.}},
series = {{Cancer Research}},
title = {{Risks for familial and contralateral breast cancer interact multiplicatively and cause a high risk}},
url = {{http://dx.doi.org/10.1158/0008-5472.CAN-06-3854}},
doi = {{10.1158/0008-5472.CAN-06-3854}},
volume = {{67}},
year = {{2007}},
}