Second primary cancers in patients with acute lymphoblastic, chronic lymphocytic and hairy cell leukaemia
(2019) In British Journal of Haematology 185(2). p.232-239- Abstract
Improvement of survival in lymphocytic leukaemia has been accompanied by the occurrence of second primary cancer (SPCs). Based on Swedish Family Cancer Database, we applied bi-directional analyses in which relative risks (RRs) were calculated for any SPCs in patients with chronic lymphocytic leukaemia (CLL), acute lymphoblastic leukaemia (ALL) and hairy cell leukaemia (HCL) and the risks of these leukaemias as SPCs. After CLL, RRs were significant for 20 SPCs, and high for skin squamous cell cancer (24·58 for in situ and 7·63 for invasive), Merkel cell carcinoma (14·36), Hodgkin lymphoma (7·16) and Kaposi sarcoma (6·76). Conversely, 15 CLL cancer pairs were reciprocally increased. The increased risks were reciprocal for ALL and four... (More)
Improvement of survival in lymphocytic leukaemia has been accompanied by the occurrence of second primary cancer (SPCs). Based on Swedish Family Cancer Database, we applied bi-directional analyses in which relative risks (RRs) were calculated for any SPCs in patients with chronic lymphocytic leukaemia (CLL), acute lymphoblastic leukaemia (ALL) and hairy cell leukaemia (HCL) and the risks of these leukaemias as SPCs. After CLL, RRs were significant for 20 SPCs, and high for skin squamous cell cancer (24·58 for in situ and 7·63 for invasive), Merkel cell carcinoma (14·36), Hodgkin lymphoma (7·16) and Kaposi sarcoma (6·76). Conversely, 15 CLL cancer pairs were reciprocally increased. The increased risks were reciprocal for ALL and four cancers. RR for ALL was 15·35 after myeloid neoplasia. HCL showed reciprocally increased RRs with non-Hodgkin lymphoma and melanoma. The concordance between RRs for bi-directional associations between CLL and different cancers, and HCL and different cancers was highly significant. For CLL (also for HCL), the bi-directional risks with skin cancers and other immune-related cancers suggest the probable involvement of immune dysfunction. For ALL, treatment may contribute to risks of multiple SPCs. Increased risk of ALL after haematological neoplasms may indicate bone marrow dysfunction. These findings may help guide treatment decisions and prognostic assessment.
(Less)
- author
- Zheng, Guoqiao LU ; Chattopadhyay, Subhayan LU ; Sud, Amit LU ; Sundquist, Kristina LU ; Sundquist, Jan LU ; Försti, Asta LU ; Houlston, Richard ; Hemminki, Akseli and Hemminki, Kari LU
- organization
- publishing date
- 2019-01-31
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- B cell leukaemia, bi-directional risk, immune suppression, mechanistic implication, second cancers
- in
- British Journal of Haematology
- volume
- 185
- issue
- 2
- pages
- 232 - 239
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85060889672
- pmid:30706458
- ISSN
- 0007-1048
- DOI
- 10.1111/bjh.15777
- language
- English
- LU publication?
- yes
- id
- c03e7e0d-b4a8-435e-a3de-ce4210e4f6fe
- date added to LUP
- 2019-02-13 10:00:14
- date last changed
- 2024-09-03 12:54:41
@article{c03e7e0d-b4a8-435e-a3de-ce4210e4f6fe, abstract = {{<p>Improvement of survival in lymphocytic leukaemia has been accompanied by the occurrence of second primary cancer (SPCs). Based on Swedish Family Cancer Database, we applied bi-directional analyses in which relative risks (RRs) were calculated for any SPCs in patients with chronic lymphocytic leukaemia (CLL), acute lymphoblastic leukaemia (ALL) and hairy cell leukaemia (HCL) and the risks of these leukaemias as SPCs. After CLL, RRs were significant for 20 SPCs, and high for skin squamous cell cancer (24·58 for in situ and 7·63 for invasive), Merkel cell carcinoma (14·36), Hodgkin lymphoma (7·16) and Kaposi sarcoma (6·76). Conversely, 15 CLL cancer pairs were reciprocally increased. The increased risks were reciprocal for ALL and four cancers. RR for ALL was 15·35 after myeloid neoplasia. HCL showed reciprocally increased RRs with non-Hodgkin lymphoma and melanoma. The concordance between RRs for bi-directional associations between CLL and different cancers, and HCL and different cancers was highly significant. For CLL (also for HCL), the bi-directional risks with skin cancers and other immune-related cancers suggest the probable involvement of immune dysfunction. For ALL, treatment may contribute to risks of multiple SPCs. Increased risk of ALL after haematological neoplasms may indicate bone marrow dysfunction. These findings may help guide treatment decisions and prognostic assessment.</p>}}, author = {{Zheng, Guoqiao and Chattopadhyay, Subhayan and Sud, Amit and Sundquist, Kristina and Sundquist, Jan and Försti, Asta and Houlston, Richard and Hemminki, Akseli and Hemminki, Kari}}, issn = {{0007-1048}}, keywords = {{B cell leukaemia; bi-directional risk; immune suppression; mechanistic implication; second cancers}}, language = {{eng}}, month = {{01}}, number = {{2}}, pages = {{232--239}}, publisher = {{Wiley-Blackwell}}, series = {{British Journal of Haematology}}, title = {{Second primary cancers in patients with acute lymphoblastic, chronic lymphocytic and hairy cell leukaemia}}, url = {{http://dx.doi.org/10.1111/bjh.15777}}, doi = {{10.1111/bjh.15777}}, volume = {{185}}, year = {{2019}}, }