Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease
Ossenkoppele, Rik LU ; Smith, Ruben LU ; Ohlsson, Tomas ; Strandberg, Olof LU ; Mattsson, Niklas LU
; Insel, Philip S.
LU
; Palmqvist, Sebastian
LU
and Hansson, Oskar
LU
(2019)
In Neurology
92(6).
p.601-612
- Abstract
OBJECTIVE: To examine the cross-sectional associations between regional tau, β-amyloid (Aβ), and cortical thickness and neuropsychological function across the preclinical and clinical spectrum of Alzheimer disease (AD). METHODS: We included 106 participants from the Swedish Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably (BioFINDER) study, of whom 33 had preclinical AD (Aβ-positive cognitively normal individuals), 25 had prodromal AD (Aβ-positive mild cognitive impairment), and 48 had probable AD dementia. All underwent [18F]flortaucipir (tau) and structural MRI (cortical thickness), and 88 of 106 underwent [18F]flutemetamol (Aβ) PET. Linear regression models adjusted for age, sex, and education were performed... (More)
OBJECTIVE: To examine the cross-sectional associations between regional tau, β-amyloid (Aβ), and cortical thickness and neuropsychological function across the preclinical and clinical spectrum of Alzheimer disease (AD). METHODS: We included 106 participants from the Swedish Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably (BioFINDER) study, of whom 33 had preclinical AD (Aβ-positive cognitively normal individuals), 25 had prodromal AD (Aβ-positive mild cognitive impairment), and 48 had probable AD dementia. All underwent [18F]flortaucipir (tau) and structural MRI (cortical thickness), and 88 of 106 underwent [18F]flutemetamol (Aβ) PET. Linear regression models adjusted for age, sex, and education were performed to examine associations between 7 regions of interest and 7 neuropsychological tests for all 3 imaging modalities. RESULTS: In preclinical AD, [18F]flortaucipir, but not [18F]flutemetamol or cortical thickness, was associated with decreased global cognition, memory, and processing speed (range standardized β = 0.35-0.52, p < 0.05 uncorrected for multiple comparisons). In the combined prodromal AD and AD dementia group, both increased [18F]flortaucipir uptake and reduced cortical thickness were associated with worse performance on a variety of neuropsychological tests (most regions of interest survived correction for multiple comparisons at p < 0.05), while increased [18F]flutemetamol uptake was specifically associated with lower scores on a delayed recall memory task (p < 0.05 uncorrected for multiple comparisons). The strongest effects for both [18F]flortaucipir and cortical thickness on cognition were found in the lateral and medial parietal cortex and lateral temporal cortex. The effect of [18F]flutemetamol on cognition was generally weaker and less region specific. CONCLUSION: Our findings suggest that tau PET is more sensitive than Aβ PET and measures of cortical thickness for detecting early cognitive changes in preclinical AD. Furthermore, both [18F]flortaucipir PET and cortical thickness show strong cognitive correlates at the clinical stages of AD.
(Less)
- author
- Ossenkoppele, Rik
LU
; Smith, Ruben
LU
; Ohlsson, Tomas
; Strandberg, Olof
LU
; Mattsson, Niklas
LU
; Insel, Philip S.
LU
; Palmqvist, Sebastian
LU
and Hansson, Oskar
LU
- organization
- publishing date
- 2019-02-09
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neurology
- volume
- 92
- issue
- 6
- pages
- 601 - 612
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:30626656
- scopus:85061155657
- ISSN
- 1526-632X
- DOI
- 10.1212/WNL.0000000000006875
- language
- English
- LU publication?
- yes
- id
- c15b7902-a40d-4729-99b5-0e6d12e0dff2
- date added to LUP
- 2019-02-15 07:31:45
- date last changed
- 2024-09-18 13:01:52
@article{c15b7902-a40d-4729-99b5-0e6d12e0dff2,
abstract = {{<p>OBJECTIVE: To examine the cross-sectional associations between regional tau, β-amyloid (Aβ), and cortical thickness and neuropsychological function across the preclinical and clinical spectrum of Alzheimer disease (AD). METHODS: We included 106 participants from the Swedish Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably (BioFINDER) study, of whom 33 had preclinical AD (Aβ-positive cognitively normal individuals), 25 had prodromal AD (Aβ-positive mild cognitive impairment), and 48 had probable AD dementia. All underwent [18F]flortaucipir (tau) and structural MRI (cortical thickness), and 88 of 106 underwent [18F]flutemetamol (Aβ) PET. Linear regression models adjusted for age, sex, and education were performed to examine associations between 7 regions of interest and 7 neuropsychological tests for all 3 imaging modalities. RESULTS: In preclinical AD, [18F]flortaucipir, but not [18F]flutemetamol or cortical thickness, was associated with decreased global cognition, memory, and processing speed (range standardized β = 0.35-0.52, p < 0.05 uncorrected for multiple comparisons). In the combined prodromal AD and AD dementia group, both increased [18F]flortaucipir uptake and reduced cortical thickness were associated with worse performance on a variety of neuropsychological tests (most regions of interest survived correction for multiple comparisons at p < 0.05), while increased [18F]flutemetamol uptake was specifically associated with lower scores on a delayed recall memory task (p < 0.05 uncorrected for multiple comparisons). The strongest effects for both [18F]flortaucipir and cortical thickness on cognition were found in the lateral and medial parietal cortex and lateral temporal cortex. The effect of [18F]flutemetamol on cognition was generally weaker and less region specific. CONCLUSION: Our findings suggest that tau PET is more sensitive than Aβ PET and measures of cortical thickness for detecting early cognitive changes in preclinical AD. Furthermore, both [18F]flortaucipir PET and cortical thickness show strong cognitive correlates at the clinical stages of AD.</p>}},
author = {{Ossenkoppele, Rik and Smith, Ruben and Ohlsson, Tomas and Strandberg, Olof and Mattsson, Niklas and Insel, Philip S. and Palmqvist, Sebastian and Hansson, Oskar}},
issn = {{1526-632X}},
language = {{eng}},
month = {{02}},
number = {{6}},
pages = {{601--612}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Neurology}},
title = {{Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease}},
url = {{http://dx.doi.org/10.1212/WNL.0000000000006875}},
doi = {{10.1212/WNL.0000000000006875}},
volume = {{92}},
year = {{2019}},
}