The serotonergic system in L-DOPA-induced dyskinesia : pre-clinical evidence and clinical perspective
Carta, Manolo and Björklund, Anders LU
(2018)
In Journal of Neural Transmission
125(8).
p.1195-1202
- Abstract
During the last decade, the serotonergic system has emerged as a key player in the appearance of L-DOPA-induced dyskinesia in animal models of Parkinson’s disease. Clinical investigations, based on imaging and postmortem analyses, suggest that the serotonin neurons are also involved in the etiology of this complication of long-term L-DOPA treatment in parkinsonian patients. These findings have stimulated efforts to develop new therapies using drugs targeting the malfunctioning serotonin neurons. In this review, we summarize the experimental and clinical data obtained so far and discuss the prospects for further development of this therapeutic strategy.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/c2b66b3c-0e64-4afc-b85d-d494e7244133
- author
- Carta, Manolo
and Björklund, Anders
LU
- organization
- publishing date
- 2018-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Dyskinesia, L-DOPA, Parkinson’s disease, Serotonin, Serotonin autoreceptors
- in
- Journal of Neural Transmission
- volume
- 125
- issue
- 8
- pages
- 1195 - 1202
- publisher
- Springer
- external identifiers
-
- pmid:29480391
- scopus:85042524623
- ISSN
- 0300-9564
- DOI
- 10.1007/s00702-018-1865-5
- language
- English
- LU publication?
- yes
- id
- c2b66b3c-0e64-4afc-b85d-d494e7244133
- date added to LUP
- 2018-03-23 13:50:15
- date last changed
- 2024-04-29 06:03:12
@article{c2b66b3c-0e64-4afc-b85d-d494e7244133,
abstract = {{<p>During the last decade, the serotonergic system has emerged as a key player in the appearance of L-DOPA-induced dyskinesia in animal models of Parkinson’s disease. Clinical investigations, based on imaging and postmortem analyses, suggest that the serotonin neurons are also involved in the etiology of this complication of long-term L-DOPA treatment in parkinsonian patients. These findings have stimulated efforts to develop new therapies using drugs targeting the malfunctioning serotonin neurons. In this review, we summarize the experimental and clinical data obtained so far and discuss the prospects for further development of this therapeutic strategy.</p>}},
author = {{Carta, Manolo and Björklund, Anders}},
issn = {{0300-9564}},
keywords = {{Dyskinesia; L-DOPA; Parkinson’s disease; Serotonin; Serotonin autoreceptors}},
language = {{eng}},
number = {{8}},
pages = {{1195--1202}},
publisher = {{Springer}},
series = {{Journal of Neural Transmission}},
title = {{The serotonergic system in L-DOPA-induced dyskinesia : pre-clinical evidence and clinical perspective}},
url = {{http://dx.doi.org/10.1007/s00702-018-1865-5}},
doi = {{10.1007/s00702-018-1865-5}},
volume = {{125}},
year = {{2018}},
}