Selective enhancement of synthesis of interleukin-2 in lymphocytes in the presence of ciprofloxacin
(1990) In European Journal of Clinical Microbiology & Infectious Diseases 9(6). p.409-413- Abstract
A study was performed to verify the effect of ciprofloxacin on the production of interleukin-2 and other cytokines in cultures of human peripheral lymphocytes. In the presence of ciprofloxacin, lymphocytes demonstrated increased synthesis of interleukin-2 (100-fold, 7-fold and 1.5-fold increase at ciprofloxacin concentrations of 80, 20 and 5 μg/ml respectively), as measured by radioimmunoassay. Synthesis of other cytokines from T lymphocytes, gamma-interferon, lymphotoxin and granulocyte-macrophage colony stimulating factor as well as interleukin-1 and tumour necrosis factor from monocytes was not increased, but inhibited at a ciprofloxacin concentration of 80 μg/ml. Thus the effect of ciprofloxacin resulting in enhanced synthesis of... (More)
A study was performed to verify the effect of ciprofloxacin on the production of interleukin-2 and other cytokines in cultures of human peripheral lymphocytes. In the presence of ciprofloxacin, lymphocytes demonstrated increased synthesis of interleukin-2 (100-fold, 7-fold and 1.5-fold increase at ciprofloxacin concentrations of 80, 20 and 5 μg/ml respectively), as measured by radioimmunoassay. Synthesis of other cytokines from T lymphocytes, gamma-interferon, lymphotoxin and granulocyte-macrophage colony stimulating factor as well as interleukin-1 and tumour necrosis factor from monocytes was not increased, but inhibited at a ciprofloxacin concentration of 80 μg/ml. Thus the effect of ciprofloxacin resulting in enhanced synthesis of interleukin-2 seems to be specific.
(Less)
- author
- Riesbeck, K. LU and Forsgren, A. LU
- organization
- publishing date
- 1990-06-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Clinical Microbiology & Infectious Diseases
- volume
- 9
- issue
- 6
- pages
- 409 - 413
- publisher
- Springer
- external identifiers
-
- scopus:0025280424
- pmid:2117532
- ISSN
- 0934-9723
- DOI
- 10.1007/BF01979471
- language
- English
- LU publication?
- yes
- id
- c351f9da-66cf-45f8-9da9-5c4c4e88c4e2
- date added to LUP
- 2019-03-27 14:25:52
- date last changed
- 2024-01-01 00:13:48
@article{c351f9da-66cf-45f8-9da9-5c4c4e88c4e2, abstract = {{<p>A study was performed to verify the effect of ciprofloxacin on the production of interleukin-2 and other cytokines in cultures of human peripheral lymphocytes. In the presence of ciprofloxacin, lymphocytes demonstrated increased synthesis of interleukin-2 (100-fold, 7-fold and 1.5-fold increase at ciprofloxacin concentrations of 80, 20 and 5 μg/ml respectively), as measured by radioimmunoassay. Synthesis of other cytokines from T lymphocytes, gamma-interferon, lymphotoxin and granulocyte-macrophage colony stimulating factor as well as interleukin-1 and tumour necrosis factor from monocytes was not increased, but inhibited at a ciprofloxacin concentration of 80 μg/ml. Thus the effect of ciprofloxacin resulting in enhanced synthesis of interleukin-2 seems to be specific.</p>}}, author = {{Riesbeck, K. and Forsgren, A.}}, issn = {{0934-9723}}, language = {{eng}}, month = {{06}}, number = {{6}}, pages = {{409--413}}, publisher = {{Springer}}, series = {{European Journal of Clinical Microbiology & Infectious Diseases}}, title = {{Selective enhancement of synthesis of interleukin-2 in lymphocytes in the presence of ciprofloxacin}}, url = {{http://dx.doi.org/10.1007/BF01979471}}, doi = {{10.1007/BF01979471}}, volume = {{9}}, year = {{1990}}, }