Nature vs nurture in knee osteoarthritis – the importance of age, sex and body mass index
(2019) In Osteoarthritis and Cartilage 27(4). p.586-592- Abstract
Objective: (1) To estimate the life-time genetic contribution for knee osteoarthritis (OA) surgery and (2) to explore any differences in the genetic contribution across age, sex and body mass index (BMI). Methods: We studied the sex-specific genetic contribution to knee OA surgery in a prospective cohort study of 62,490 twins aged 35 years or older with a follow-up period of up to 47 years (10,092 identical and 21,153 non-identical twin pairs, 54% women). To study interactions with age, we graphed the heritabilities over the lifespan for men and women. We also studied the sex-specific heritability across strata of the median BMI to explore any interactions with BMI. Results: The overall heritability of knee OA surgery was 0.53 (95%... (More)
Objective: (1) To estimate the life-time genetic contribution for knee osteoarthritis (OA) surgery and (2) to explore any differences in the genetic contribution across age, sex and body mass index (BMI). Methods: We studied the sex-specific genetic contribution to knee OA surgery in a prospective cohort study of 62,490 twins aged 35 years or older with a follow-up period of up to 47 years (10,092 identical and 21,153 non-identical twin pairs, 54% women). To study interactions with age, we graphed the heritabilities over the lifespan for men and women. We also studied the sex-specific heritability across strata of the median BMI to explore any interactions with BMI. Results: The overall heritability of knee OA surgery was 0.53 (95% confidence intervals [CI] = 0.31–0.75), with higher heritability among women (H2 = 0.80 (95% CI = 0.73–0.87)) than men (H2 = 0.39 (95% CI = 0.10–0.69)). For men, the heritability started to rise after age 68. The genetic contribution was particularly low in men above median BMI (H2
(Less)
≥23.7 kg/m2 = 0.08, 95% CI = −0.32–0.48). For women, the heritability was consistently high from age 50 to death, independently of BMI (H2
≥22.5 kg/m2 = 0.77, 95% CI = 0.66–0.87). Conclusion: There is a higher and more consistent genetic contribution for knee OA surgery in women than men. In men the genetic contribution was relatively low and varied with age and BMI.
- author
- Magnusson, K. LU ; Turkiewicz, A. LU and Englund, M. LU
- organization
- publishing date
- 2019-01-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Gene-environment interaction, Genetics, Heritability, Knee osteoarthritis
- in
- Osteoarthritis and Cartilage
- volume
- 27
- issue
- 4
- pages
- 586 - 592
- publisher
- Elsevier
- external identifiers
-
- scopus:85060337386
- pmid:30634033
- ISSN
- 1063-4584
- DOI
- 10.1016/j.joca.2018.12.018
- language
- English
- LU publication?
- yes
- id
- c4138f5b-506c-4fa5-b3c0-358f6ec18499
- date added to LUP
- 2019-02-01 11:04:23
- date last changed
- 2024-08-20 09:24:44
@article{c4138f5b-506c-4fa5-b3c0-358f6ec18499, abstract = {{<p>Objective: (1) To estimate the life-time genetic contribution for knee osteoarthritis (OA) surgery and (2) to explore any differences in the genetic contribution across age, sex and body mass index (BMI). Methods: We studied the sex-specific genetic contribution to knee OA surgery in a prospective cohort study of 62,490 twins aged 35 years or older with a follow-up period of up to 47 years (10,092 identical and 21,153 non-identical twin pairs, 54% women). To study interactions with age, we graphed the heritabilities over the lifespan for men and women. We also studied the sex-specific heritability across strata of the median BMI to explore any interactions with BMI. Results: The overall heritability of knee OA surgery was 0.53 (95% confidence intervals [CI] = 0.31–0.75), with higher heritability among women (H<sup>2</sup> = 0.80 (95% CI = 0.73–0.87)) than men (H<sup>2</sup> = 0.39 (95% CI = 0.10–0.69)). For men, the heritability started to rise after age 68. The genetic contribution was particularly low in men above median BMI (H<sup>2</sup><br> <sub>≥23.7 kg/m2</sub> = 0.08, 95% CI = −0.32–0.48). For women, the heritability was consistently high from age 50 to death, independently of BMI (H<sup>2</sup><br> <sub>≥22.5 kg/m2</sub> = 0.77, 95% CI = 0.66–0.87). Conclusion: There is a higher and more consistent genetic contribution for knee OA surgery in women than men. In men the genetic contribution was relatively low and varied with age and BMI.</p>}}, author = {{Magnusson, K. and Turkiewicz, A. and Englund, M.}}, issn = {{1063-4584}}, keywords = {{Gene-environment interaction; Genetics; Heritability; Knee osteoarthritis}}, language = {{eng}}, month = {{01}}, number = {{4}}, pages = {{586--592}}, publisher = {{Elsevier}}, series = {{Osteoarthritis and Cartilage}}, title = {{Nature vs nurture in knee osteoarthritis – the importance of age, sex and body mass index}}, url = {{http://dx.doi.org/10.1016/j.joca.2018.12.018}}, doi = {{10.1016/j.joca.2018.12.018}}, volume = {{27}}, year = {{2019}}, }