Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells
(2014) In Stem Cell Reports 2(6). p.93-780- Abstract
Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.
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https://lup.lub.lu.se/record/c587f856-f990-4dbc-ae05-22dc3c73f9f9
- author
- organization
- publishing date
- 2014-06-03
- type
- Contribution to journal
- publication status
- published
- keywords
- Cell Proliferation, Cells, Cultured, Human Growth Hormone, Humans, Mammary Glands, Human, Progesterone, Stem Cells, Journal Article, Research Support, Non-U.S. Gov't
- in
- Stem Cell Reports
- volume
- 2
- issue
- 6
- pages
- 14 pages
- publisher
- Cell Press
- external identifiers
-
- pmid:24936466
- scopus:84902204202
- ISSN
- 2213-6711
- DOI
- 10.1016/j.stemcr.2014.05.005
- language
- English
- LU publication?
- no
- id
- c587f856-f990-4dbc-ae05-22dc3c73f9f9
- date added to LUP
- 2016-11-25 16:49:36
- date last changed
- 2024-08-09 23:33:12
@article{c587f856-f990-4dbc-ae05-22dc3c73f9f9, abstract = {{<p>Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.</p>}}, author = {{Lombardi, Sara and Honeth, Gabriella and Ginestier, Christophe and Shinomiya, Ireneusz and Marlow, Rebecca and Buchupalli, Bharath and Gazinska, Patrycja and Brown, John and Catchpole, Steven and Liu, Suling and Barkan, Ariel and Wicha, Max and Purushotham, Anand and Burchell, Joy and Pinder, Sarah and Dontu, Gabriela}}, issn = {{2213-6711}}, keywords = {{Cell Proliferation; Cells, Cultured; Human Growth Hormone; Humans; Mammary Glands, Human; Progesterone; Stem Cells; Journal Article; Research Support, Non-U.S. Gov't}}, language = {{eng}}, month = {{06}}, number = {{6}}, pages = {{93--780}}, publisher = {{Cell Press}}, series = {{Stem Cell Reports}}, title = {{Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells}}, url = {{http://dx.doi.org/10.1016/j.stemcr.2014.05.005}}, doi = {{10.1016/j.stemcr.2014.05.005}}, volume = {{2}}, year = {{2014}}, }