Uptake of nanowires by human lung adenocarcinoma cells
(2019) In PLoS ONE 14(6).- Abstract
Semiconductor nanowires are increasingly used in optoelectronic devices. However, their effects on human health have not been assessed fully. Here, we investigate the effects of gallium phosphide nanowires on human lung adenocarcinoma cells. Four different geometries of nanowires were suspended in the cell culture for 48 hours. We show that cells internalize the nanowires and that the nanowires have no effect on cell proliferation rate, motility, viability and intracellular ROS levels. By blocking specific internalization pathways, we demonstrate that the nanowire uptake is the result of a combination of processes, requiring dynamin and actin polymerization, which suggests an internalization through macropinocytosis and phagocytosis.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/c88cd6f5-ad90-4f80-a818-a94840087a75
- author
- Abariute, Laura LU ; Lard, Mercy LU ; Hebisch, Elke LU and Prinz, Christelle N. LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 14
- issue
- 6
- article number
- e0218122
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:31226121
- scopus:85067605289
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0218122
- language
- English
- LU publication?
- yes
- id
- c88cd6f5-ad90-4f80-a818-a94840087a75
- date added to LUP
- 2019-07-05 11:04:12
- date last changed
- 2024-08-21 03:28:08
@article{c88cd6f5-ad90-4f80-a818-a94840087a75, abstract = {{<p>Semiconductor nanowires are increasingly used in optoelectronic devices. However, their effects on human health have not been assessed fully. Here, we investigate the effects of gallium phosphide nanowires on human lung adenocarcinoma cells. Four different geometries of nanowires were suspended in the cell culture for 48 hours. We show that cells internalize the nanowires and that the nanowires have no effect on cell proliferation rate, motility, viability and intracellular ROS levels. By blocking specific internalization pathways, we demonstrate that the nanowire uptake is the result of a combination of processes, requiring dynamin and actin polymerization, which suggests an internalization through macropinocytosis and phagocytosis.</p>}}, author = {{Abariute, Laura and Lard, Mercy and Hebisch, Elke and Prinz, Christelle N.}}, issn = {{1932-6203}}, language = {{eng}}, number = {{6}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Uptake of nanowires by human lung adenocarcinoma cells}}, url = {{http://dx.doi.org/10.1371/journal.pone.0218122}}, doi = {{10.1371/journal.pone.0218122}}, volume = {{14}}, year = {{2019}}, }