Impaired nerve regeneration in streptozotocin-diabetic rats is improved by treatment with gangliosides
(1990) In Experimental Neurology 109(2). p.200-203- Abstract
The rate of sciatic nerve regeneration and the effect of ganglioside treatment thereon were studied in the streptozotocin-diabetic rat. Two experimental protocols were used. In the first, sciatic nerves were crushed at 3 weeks of diabetes and treatment with purified bovine brain gangliosides (10 mg/kg/day ip) was begun the day before crush. In the second, nerves were crushed at 5 weeks of diabetes and treatment was started 7 days before crush. Regeneration was evaluated in both cases with the pinch-reflex test at different time points after crush. In either situation untreated diabetic rats showed a decreased rate of regeneration when compared to untreated nondiabetic rats, with a more severe reduction in 5-week diabetic rats.... (More)
The rate of sciatic nerve regeneration and the effect of ganglioside treatment thereon were studied in the streptozotocin-diabetic rat. Two experimental protocols were used. In the first, sciatic nerves were crushed at 3 weeks of diabetes and treatment with purified bovine brain gangliosides (10 mg/kg/day ip) was begun the day before crush. In the second, nerves were crushed at 5 weeks of diabetes and treatment was started 7 days before crush. Regeneration was evaluated in both cases with the pinch-reflex test at different time points after crush. In either situation untreated diabetic rats showed a decreased rate of regeneration when compared to untreated nondiabetic rats, with a more severe reduction in 5-week diabetic rats. Ganglioside treatment improved regeneration in the second protocol; untreated diabetic rats had regenerated 10.6 ±0.9 mm (mean ± SEM) at 7 days postcrush, while nerves from ganglioside-treated and control rats had regenerated 16.4 ± 1.1 and 20.3 ± 1.0 mm, respectively (n = 9-11, P < 0.001 for untreated vs ganglioside-treated diabetics with two-way ANOVA). Ganglioside treatment did not alter the rate of regeneration in nondiabetic rats.
(Less)
- author
- Ekström, Per A R LU and Tomlinson, David R.
- organization
- publishing date
- 1990
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Experimental Neurology
- volume
- 109
- issue
- 2
- pages
- 200 - 203
- publisher
- Elsevier
- external identifiers
-
- scopus:0025180063
- pmid:2379556
- ISSN
- 0014-4886
- DOI
- 10.1016/0014-4886(90)90074-3
- language
- English
- LU publication?
- no
- id
- c9b0de33-02ff-4677-9f89-1aea3e9b4d2e
- date added to LUP
- 2016-12-07 14:33:55
- date last changed
- 2024-01-04 18:19:14
@article{c9b0de33-02ff-4677-9f89-1aea3e9b4d2e, abstract = {{<p>The rate of sciatic nerve regeneration and the effect of ganglioside treatment thereon were studied in the streptozotocin-diabetic rat. Two experimental protocols were used. In the first, sciatic nerves were crushed at 3 weeks of diabetes and treatment with purified bovine brain gangliosides (10 mg/kg/day ip) was begun the day before crush. In the second, nerves were crushed at 5 weeks of diabetes and treatment was started 7 days before crush. Regeneration was evaluated in both cases with the pinch-reflex test at different time points after crush. In either situation untreated diabetic rats showed a decreased rate of regeneration when compared to untreated nondiabetic rats, with a more severe reduction in 5-week diabetic rats. Ganglioside treatment improved regeneration in the second protocol; untreated diabetic rats had regenerated 10.6 ±0.9 mm (mean ± SEM) at 7 days postcrush, while nerves from ganglioside-treated and control rats had regenerated 16.4 ± 1.1 and 20.3 ± 1.0 mm, respectively (n = 9-11, P < 0.001 for untreated vs ganglioside-treated diabetics with two-way ANOVA). Ganglioside treatment did not alter the rate of regeneration in nondiabetic rats.</p>}}, author = {{Ekström, Per A R and Tomlinson, David R.}}, issn = {{0014-4886}}, language = {{eng}}, number = {{2}}, pages = {{200--203}}, publisher = {{Elsevier}}, series = {{Experimental Neurology}}, title = {{Impaired nerve regeneration in streptozotocin-diabetic rats is improved by treatment with gangliosides}}, url = {{http://dx.doi.org/10.1016/0014-4886(90)90074-3}}, doi = {{10.1016/0014-4886(90)90074-3}}, volume = {{109}}, year = {{1990}}, }