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Acoustophoresis in tumor cell enrichment

Augustsson, Per LU ; Magnusson, Cecilia LU ; Lilja, Hans LU orcid and Laurell, Thomas LU (2016) p.227-248
Abstract
This chapter outlines the opportunities and current developments of label-free separation of circulating tumor cell (CTC) from blood cells using acoustophoresis. It describes two platforms that have been developed to enable subsequent evaluation of acoustophoresis in clinical settings. All nucleated cells in suspension flow along a microchannel wherein the cells are exposed to an acoustic field. The individual cells experience a force that is perpendicular to the flow, which deflects the cells sideways at a magnitude that depends on the size and acoustic properties of the cell. The chapter describes the acoustic field, the acoustic radiation force on a cell, and the influence of the laminar flow on separation outcome. Microchannel... (More)
This chapter outlines the opportunities and current developments of label-free separation of circulating tumor cell (CTC) from blood cells using acoustophoresis. It describes two platforms that have been developed to enable subsequent evaluation of acoustophoresis in clinical settings. All nucleated cells in suspension flow along a microchannel wherein the cells are exposed to an acoustic field. The individual cells experience a force that is perpendicular to the flow, which deflects the cells sideways at a magnitude that depends on the size and acoustic properties of the cell. The chapter describes the acoustic field, the acoustic radiation force on a cell, and the influence of the laminar flow on separation outcome. Microchannel acoustophoresis has been evaluated for isolation of prostate and breast cancer cells from blood. Cancer cells are discriminated primarily based on their higher acoustophoretic mobility as compared to the white blood cells (WBCs). (Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Circulating Tumor Cells : Isolation and Analysis - Isolation and Analysis
pages
227 - 248
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:105007763792
ISBN
9781118915530
9781119244554
DOI
10.1002/9781119244554.ch10
language
English
LU publication?
yes
id
ce7f4866-9c4a-432e-a409-7e804f065e44
date added to LUP
2025-06-23 12:20:22
date last changed
2025-06-25 02:44:43
@inbook{ce7f4866-9c4a-432e-a409-7e804f065e44,
  abstract     = {{This chapter outlines the opportunities and current developments of label-free separation of circulating tumor cell (CTC) from blood cells using acoustophoresis. It describes two platforms that have been developed to enable subsequent evaluation of acoustophoresis in clinical settings. All nucleated cells in suspension flow along a microchannel wherein the cells are exposed to an acoustic field. The individual cells experience a force that is perpendicular to the flow, which deflects the cells sideways at a magnitude that depends on the size and acoustic properties of the cell. The chapter describes the acoustic field, the acoustic radiation force on a cell, and the influence of the laminar flow on separation outcome. Microchannel acoustophoresis has been evaluated for isolation of prostate and breast cancer cells from blood. Cancer cells are discriminated primarily based on their higher acoustophoretic mobility as compared to the white blood cells (WBCs).}},
  author       = {{Augustsson, Per and Magnusson, Cecilia and Lilja, Hans and Laurell, Thomas}},
  booktitle    = {{Circulating Tumor Cells : Isolation and Analysis}},
  isbn         = {{9781118915530}},
  language     = {{eng}},
  month        = {{04}},
  pages        = {{227--248}},
  publisher    = {{John Wiley & Sons Inc.}},
  title        = {{Acoustophoresis in tumor cell enrichment}},
  url          = {{http://dx.doi.org/10.1002/9781119244554.ch10}},
  doi          = {{10.1002/9781119244554.ch10}},
  year         = {{2016}},
}