'From blood to blood' : De-differentiation of hematopoietic progenitors to stem cells
Pereira, Carlos Filipe LU
; Lemischka, Ihor R.
and Moore, Kateri
(2014)
In EMBO Journal
33(14).
p.1511-1513
- Abstract
Recent studies have reported that fibroblasts or differentiated pluripotent cells can be reprogrammed with transcription factors (TFs) into cells with hematopoietic potential. A study published in Cell now suggests that committed blood precursors may provide a source for blood stem cell transplantation after reprogramming (Riddell et al, 2014). The authors report that a combination of eight TFs reprogram murine committed blood progenitors into long-term engrafting and serially transplantable hematopoietic stem cells with a molecular signature similar to their endogenous counterparts.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/cefe6a97-9e37-4216-9a68-c5968e171996
- author
- Pereira, Carlos Filipe
LU
; Lemischka, Ihor R.
and Moore, Kateri
- publishing date
- 2014-07-17
- type
- Contribution to journal
- publication status
- published
- in
- EMBO Journal
- volume
- 33
- issue
- 14
- pages
- 3 pages
- publisher
- Oxford University Press
- external identifiers
-
- pmid:24907133
- scopus:84904561142
- ISSN
- 0261-4189
- DOI
- 10.15252/embj.201488980
- language
- English
- LU publication?
- no
- id
- cefe6a97-9e37-4216-9a68-c5968e171996
- date added to LUP
- 2017-10-02 17:26:31
- date last changed
- 2024-01-14 06:08:33
@article{cefe6a97-9e37-4216-9a68-c5968e171996,
abstract = {{<p>Recent studies have reported that fibroblasts or differentiated pluripotent cells can be reprogrammed with transcription factors (TFs) into cells with hematopoietic potential. A study published in Cell now suggests that committed blood precursors may provide a source for blood stem cell transplantation after reprogramming (Riddell et al, 2014). The authors report that a combination of eight TFs reprogram murine committed blood progenitors into long-term engrafting and serially transplantable hematopoietic stem cells with a molecular signature similar to their endogenous counterparts.</p>}},
author = {{Pereira, Carlos Filipe and Lemischka, Ihor R. and Moore, Kateri}},
issn = {{0261-4189}},
language = {{eng}},
month = {{07}},
number = {{14}},
pages = {{1511--1513}},
publisher = {{Oxford University Press}},
series = {{EMBO Journal}},
title = {{'From blood to blood' : De-differentiation of hematopoietic progenitors to stem cells}},
url = {{http://dx.doi.org/10.15252/embj.201488980}},
doi = {{10.15252/embj.201488980}},
volume = {{33}},
year = {{2014}},
}