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From immune activation to disease progression : Unraveling the complex role of Serum Amyloid A proteins

Papareddy, Praveen LU orcid and Herwald, Heiko LU orcid (2025) In Cytokine & Growth Factor Reviews
Abstract

Serum Amyloid A (SAA) proteins are critical mediators of immune activation and metabolic regulation, bridging the acute-phase response with long-term disease dynamics. Once considered mere biomarkers of inflammation, emerging research has revealed their central role in orchestrating immune responses, lipid metabolism, and tissue remodeling. SAA proteins display context-dependent functions: they promote immune defense and tissue regeneration in some conditions, while exacerbating chronic inflammation and disease progression in others. Recent studies highlight the intricate interplay between SAA isoforms, pattern recognition receptors, and metabolic pathways, with implications for autoimmune diseases, metabolic disorders, and inflammatory... (More)

Serum Amyloid A (SAA) proteins are critical mediators of immune activation and metabolic regulation, bridging the acute-phase response with long-term disease dynamics. Once considered mere biomarkers of inflammation, emerging research has revealed their central role in orchestrating immune responses, lipid metabolism, and tissue remodeling. SAA proteins display context-dependent functions: they promote immune defense and tissue regeneration in some conditions, while exacerbating chronic inflammation and disease progression in others. Recent studies highlight the intricate interplay between SAA isoforms, pattern recognition receptors, and metabolic pathways, with implications for autoimmune diseases, metabolic disorders, and inflammatory pathologies. Despite their well-documented role in acute inflammation, the therapeutic potential of SAA proteins remains underexplored. Ongoing research aims to dissect their multifaceted functions and isoform-specific effects, paving the way for novel diagnostic and therapeutic strategies in immune-mediated diseases.

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Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Cytokine & Growth Factor Reviews
publisher
Elsevier
external identifiers
  • scopus:105002671724
  • pmid:40240198
ISSN
1359-6101
DOI
10.1016/j.cytogfr.2025.03.003
language
English
LU publication?
yes
additional info
Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.
id
d0d33e90-f561-4480-9ce2-905bce65bc21
date added to LUP
2025-05-01 14:40:24
date last changed
2025-05-06 02:58:20
@article{d0d33e90-f561-4480-9ce2-905bce65bc21,
  abstract     = {{<p>Serum Amyloid A (SAA) proteins are critical mediators of immune activation and metabolic regulation, bridging the acute-phase response with long-term disease dynamics. Once considered mere biomarkers of inflammation, emerging research has revealed their central role in orchestrating immune responses, lipid metabolism, and tissue remodeling. SAA proteins display context-dependent functions: they promote immune defense and tissue regeneration in some conditions, while exacerbating chronic inflammation and disease progression in others. Recent studies highlight the intricate interplay between SAA isoforms, pattern recognition receptors, and metabolic pathways, with implications for autoimmune diseases, metabolic disorders, and inflammatory pathologies. Despite their well-documented role in acute inflammation, the therapeutic potential of SAA proteins remains underexplored. Ongoing research aims to dissect their multifaceted functions and isoform-specific effects, paving the way for novel diagnostic and therapeutic strategies in immune-mediated diseases.</p>}},
  author       = {{Papareddy, Praveen and Herwald, Heiko}},
  issn         = {{1359-6101}},
  language     = {{eng}},
  month        = {{04}},
  publisher    = {{Elsevier}},
  series       = {{Cytokine & Growth Factor Reviews}},
  title        = {{From immune activation to disease progression : Unraveling the complex role of Serum Amyloid A proteins}},
  url          = {{http://dx.doi.org/10.1016/j.cytogfr.2025.03.003}},
  doi          = {{10.1016/j.cytogfr.2025.03.003}},
  year         = {{2025}},
}