Estimating burden of influenza-associated influenza-like illness and severe acute respiratory infection at public healthcare facilities in Romania during the 2011/12-2015/16 influenza seasons
(2018) In Influenza and other Respiratory Viruses 12(1). p.183-192- Abstract
Background: Influenza is responsible for substantial morbidity and mortality, but there is limited information on reliable disease burden estimates, especially from middle-income countries in the WHO European Region. Objectives: To estimate the incidence of medically attended influenza-associated influenza-like illness (ILI) and hospitalizations due to severe acute respiratory infection (SARI) presenting to public healthcare facilities in Romania. Patients/Methods: Sentinel influenza surveillance data for ILI and SARI from 2011/12-2015/16, including virological data, were used to estimate influenza-associated ILI and SARI incidence/100 000 and their 95% confidence intervals (95% CI). Results: The overall annual incidence of ILI and... (More)
Background: Influenza is responsible for substantial morbidity and mortality, but there is limited information on reliable disease burden estimates, especially from middle-income countries in the WHO European Region. Objectives: To estimate the incidence of medically attended influenza-associated influenza-like illness (ILI) and hospitalizations due to severe acute respiratory infection (SARI) presenting to public healthcare facilities in Romania. Patients/Methods: Sentinel influenza surveillance data for ILI and SARI from 2011/12-2015/16, including virological data, were used to estimate influenza-associated ILI and SARI incidence/100 000 and their 95% confidence intervals (95% CI). Results: The overall annual incidence of ILI and influenza-associated ILI per 100 000 persons in Romania varied between 68 (95% CI: 61-76) and 318 (95% CI: 298-338) and between 23 (95% CI: 19-29) and 189 (95% CI: 149-240), respectively. The highest ILI and influenza incidence was among children aged 0-4 years. We estimated that SARI incidence per 100 000 persons was 6 (95% CI: 5-7) to 9 (95% CI: 8-10), of which 2 (95% CI: 1-2) to 3 (95% CI: 2-4) were due to influenza. Up to 0.3% of the Romanian population were annually reported with ILI, and 0.01% was hospitalized with SARI, of which as much as one-third could be explained by influenza. Conclusions: This evaluation was the first study estimating influenza burden in Romania. We found that during each influenza season, a substantial number of persons in Romania suffer from influenza-related ILI or are hospitalized due to influenza-associated SARI.
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- author
- Gefenaite, Giedre LU ; Pistol, Adriana ; Popescu, Rodica ; Popovici, Odette ; Ciurea, Daniel ; Dolk, Christiaan ; Jit, Mark and Gross, Diane
- organization
- publishing date
- 2018-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Burden, Influenza-like illness, Severe acute respiratory infection
- in
- Influenza and other Respiratory Viruses
- volume
- 12
- issue
- 1
- pages
- 183 - 192
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:29144598
- scopus:85041170818
- ISSN
- 1750-2640
- DOI
- 10.1111/irv.12525
- project
- Infectious diseases surveillance, vaccine effectiveness and determinants of acceptance
- language
- English
- LU publication?
- yes
- id
- d59dd31b-15d6-4947-901f-7ab30c1a036f
- date added to LUP
- 2018-02-23 09:25:37
- date last changed
- 2024-04-15 02:39:16
@article{d59dd31b-15d6-4947-901f-7ab30c1a036f, abstract = {{<p>Background: Influenza is responsible for substantial morbidity and mortality, but there is limited information on reliable disease burden estimates, especially from middle-income countries in the WHO European Region. Objectives: To estimate the incidence of medically attended influenza-associated influenza-like illness (ILI) and hospitalizations due to severe acute respiratory infection (SARI) presenting to public healthcare facilities in Romania. Patients/Methods: Sentinel influenza surveillance data for ILI and SARI from 2011/12-2015/16, including virological data, were used to estimate influenza-associated ILI and SARI incidence/100 000 and their 95% confidence intervals (95% CI). Results: The overall annual incidence of ILI and influenza-associated ILI per 100 000 persons in Romania varied between 68 (95% CI: 61-76) and 318 (95% CI: 298-338) and between 23 (95% CI: 19-29) and 189 (95% CI: 149-240), respectively. The highest ILI and influenza incidence was among children aged 0-4 years. We estimated that SARI incidence per 100 000 persons was 6 (95% CI: 5-7) to 9 (95% CI: 8-10), of which 2 (95% CI: 1-2) to 3 (95% CI: 2-4) were due to influenza. Up to 0.3% of the Romanian population were annually reported with ILI, and 0.01% was hospitalized with SARI, of which as much as one-third could be explained by influenza. Conclusions: This evaluation was the first study estimating influenza burden in Romania. We found that during each influenza season, a substantial number of persons in Romania suffer from influenza-related ILI or are hospitalized due to influenza-associated SARI.</p>}}, author = {{Gefenaite, Giedre and Pistol, Adriana and Popescu, Rodica and Popovici, Odette and Ciurea, Daniel and Dolk, Christiaan and Jit, Mark and Gross, Diane}}, issn = {{1750-2640}}, keywords = {{Burden; Influenza-like illness; Severe acute respiratory infection}}, language = {{eng}}, number = {{1}}, pages = {{183--192}}, publisher = {{Wiley-Blackwell}}, series = {{Influenza and other Respiratory Viruses}}, title = {{Estimating burden of influenza-associated influenza-like illness and severe acute respiratory infection at public healthcare facilities in Romania during the 2011/12-2015/16 influenza seasons}}, url = {{http://dx.doi.org/10.1111/irv.12525}}, doi = {{10.1111/irv.12525}}, volume = {{12}}, year = {{2018}}, }