How bacteria hack the matrix and dodge the bullets of immunity
Paulsson, Magnus LU
and Riesbeck, Kristian
LU
(2018)
In European Respiratory Review
27(148).
- Abstract
Haemophilus influenzae, Moraxella catarrhalis and Pseudomonas aeruginosa are common Gram-negative pathogens associated with an array of pulmonary diseases. All three species have multiple adhesins in their outer membrane, i.e. surface structures that confer the ability to bind to surrounding cells, proteins or tissues. This mini-review focuses on proteins with high affinity for the components of the extracellular matrix such as collagen, laminin, fibronectin and vitronectin. Adhesins are not structurally related and may be lipoproteins, transmembrane porins or large protruding trimeric auto-transporters. They enable bacteria to avoid being cleared together with mucus by attaching to patches of exposed extracellular matrix, or indirectly... (More)
Haemophilus influenzae, Moraxella catarrhalis and Pseudomonas aeruginosa are common Gram-negative pathogens associated with an array of pulmonary diseases. All three species have multiple adhesins in their outer membrane, i.e. surface structures that confer the ability to bind to surrounding cells, proteins or tissues. This mini-review focuses on proteins with high affinity for the components of the extracellular matrix such as collagen, laminin, fibronectin and vitronectin. Adhesins are not structurally related and may be lipoproteins, transmembrane porins or large protruding trimeric auto-transporters. They enable bacteria to avoid being cleared together with mucus by attaching to patches of exposed extracellular matrix, or indirectly adhering to epithelial cells using matrix proteins as bridging molecules. As more adhesins are being unravelled, it is apparent that bacterial adhesion is a highly conserved mechanism, and that most adhesins target the same regions on the proteins of the extracellular matrix. The surface exposed adhesins are prime targets for new vaccines and the interactions between proteins are often possible to inhibit with interfering molecules, e.g. heparin. In conclusion, this highly interesting research field of microbiology has unravelled host–pathogen interactions with high therapeutic potential.
(Less)
- author
- Paulsson, Magnus
LU
and Riesbeck, Kristian
LU
- organization
- publishing date
- 2018-06
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Respiratory Review
- volume
- 27
- issue
- 148
- article number
- 180018
- publisher
- European Respiratory Society
- external identifiers
-
- scopus:85050029207
- pmid:29950304
- ISSN
- 0905-9180
- DOI
- 10.1183/16000617.0018-2018
- project
- The Extracellular Matrix in Patients with CF or COPD as a Basis for Novel Therapeutical Opportunities
- language
- English
- LU publication?
- yes
- id
- d6ff472c-51e0-4220-82f2-5ab53fc2e6a2
- date added to LUP
- 2018-08-02 11:11:07
- date last changed
- 2024-03-18 12:34:21
@article{d6ff472c-51e0-4220-82f2-5ab53fc2e6a2,
abstract = {{<p>Haemophilus influenzae, Moraxella catarrhalis and Pseudomonas aeruginosa are common Gram-negative pathogens associated with an array of pulmonary diseases. All three species have multiple adhesins in their outer membrane, i.e. surface structures that confer the ability to bind to surrounding cells, proteins or tissues. This mini-review focuses on proteins with high affinity for the components of the extracellular matrix such as collagen, laminin, fibronectin and vitronectin. Adhesins are not structurally related and may be lipoproteins, transmembrane porins or large protruding trimeric auto-transporters. They enable bacteria to avoid being cleared together with mucus by attaching to patches of exposed extracellular matrix, or indirectly adhering to epithelial cells using matrix proteins as bridging molecules. As more adhesins are being unravelled, it is apparent that bacterial adhesion is a highly conserved mechanism, and that most adhesins target the same regions on the proteins of the extracellular matrix. The surface exposed adhesins are prime targets for new vaccines and the interactions between proteins are often possible to inhibit with interfering molecules, e.g. heparin. In conclusion, this highly interesting research field of microbiology has unravelled host–pathogen interactions with high therapeutic potential.</p>}},
author = {{Paulsson, Magnus and Riesbeck, Kristian}},
issn = {{0905-9180}},
language = {{eng}},
number = {{148}},
publisher = {{European Respiratory Society}},
series = {{European Respiratory Review}},
title = {{How bacteria hack the matrix and dodge the bullets of immunity}},
url = {{http://dx.doi.org/10.1183/16000617.0018-2018}},
doi = {{10.1183/16000617.0018-2018}},
volume = {{27}},
year = {{2018}},
}