Prevalence of high-risk HPV in postmenopausal women with benign cervical cytology - A population-based cohort study
(2018) In Anticancer research 38(7). p.4221-4228- Abstract
Aim: To compare the clinical performance of human papillomavirus (HPV) mRNA and DNA assays in postmenopausal women. Materials and Methods: A total of 5,925 postmenopausal women were tested with cytology and the Luminex HPV DNA assay. High risk-HPV-positive women with benign cytology underwent a complimentary HPV mRNA assay (APTIMA). Both assays and the cytological testing were repeated after 12 months. Results: A total of 334 women were found to be high-risk HPV-positive; 272 out of these women met the inclusion criteria. At follow-up, 25 (9.2%) out of the 272 included women had cytological abnormalities. HPV mRNA assay at follow-up had a sensitivity of 84% (95% confidence interval=63.9-95.4%) and a specificity of 60.2% (95% confidence... (More)
Aim: To compare the clinical performance of human papillomavirus (HPV) mRNA and DNA assays in postmenopausal women. Materials and Methods: A total of 5,925 postmenopausal women were tested with cytology and the Luminex HPV DNA assay. High risk-HPV-positive women with benign cytology underwent a complimentary HPV mRNA assay (APTIMA). Both assays and the cytological testing were repeated after 12 months. Results: A total of 334 women were found to be high-risk HPV-positive; 272 out of these women met the inclusion criteria. At follow-up, 25 (9.2%) out of the 272 included women had cytological abnormalities. HPV mRNA assay at follow-up had a sensitivity of 84% (95% confidence interval=63.9-95.4%) and a specificity of 60.2% (95% confidence interval=53.7-66.3%; p=0.0003) to detect these lesions. Corresponding values for the HPV DNA assay were 88% (95% confidence interval=68.8-97.4%) and 43.5% (95% confidence interval=37.2-49.4%). Conclusion: The HPV mRNA assay offers a comparable sensitivity but a higher specificity than the HPV DNA assay in detecting precancerous cervical lesions.
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- author
- Asciutto, Katrin Christine LU ; Forslund, Ola LU and Borgfeldt, Christer LU
- organization
- publishing date
- 2018-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- High-risk HPV, HPV DNA, mRNA testing, Postmenopausal women
- in
- Anticancer research
- volume
- 38
- issue
- 7
- pages
- 8 pages
- publisher
- International Institute of Cancer Research
- external identifiers
-
- pmid:29970554
- scopus:85049798970
- ISSN
- 0250-7005
- DOI
- 10.21873/anticanres.12718
- language
- English
- LU publication?
- yes
- id
- d72a21cc-2bfb-47d6-90af-cb10f8cb20a0
- date added to LUP
- 2018-09-07 12:33:29
- date last changed
- 2024-07-22 21:33:00
@article{d72a21cc-2bfb-47d6-90af-cb10f8cb20a0, abstract = {{<p>Aim: To compare the clinical performance of human papillomavirus (HPV) mRNA and DNA assays in postmenopausal women. Materials and Methods: A total of 5,925 postmenopausal women were tested with cytology and the Luminex HPV DNA assay. High risk-HPV-positive women with benign cytology underwent a complimentary HPV mRNA assay (APTIMA). Both assays and the cytological testing were repeated after 12 months. Results: A total of 334 women were found to be high-risk HPV-positive; 272 out of these women met the inclusion criteria. At follow-up, 25 (9.2%) out of the 272 included women had cytological abnormalities. HPV mRNA assay at follow-up had a sensitivity of 84% (95% confidence interval=63.9-95.4%) and a specificity of 60.2% (95% confidence interval=53.7-66.3%; p=0.0003) to detect these lesions. Corresponding values for the HPV DNA assay were 88% (95% confidence interval=68.8-97.4%) and 43.5% (95% confidence interval=37.2-49.4%). Conclusion: The HPV mRNA assay offers a comparable sensitivity but a higher specificity than the HPV DNA assay in detecting precancerous cervical lesions.</p>}}, author = {{Asciutto, Katrin Christine and Forslund, Ola and Borgfeldt, Christer}}, issn = {{0250-7005}}, keywords = {{High-risk HPV; HPV DNA; mRNA testing; Postmenopausal women}}, language = {{eng}}, month = {{07}}, number = {{7}}, pages = {{4221--4228}}, publisher = {{International Institute of Cancer Research}}, series = {{Anticancer research}}, title = {{Prevalence of high-risk HPV in postmenopausal women with benign cervical cytology - A population-based cohort study}}, url = {{http://dx.doi.org/10.21873/anticanres.12718}}, doi = {{10.21873/anticanres.12718}}, volume = {{38}}, year = {{2018}}, }