Synthesis of fluorescent molecularly imprinted nanoparticles for turn-on fluorescence assay using one-pot synthetic method and a preliminary microfluidic approach
(2018) In Polymer 138. p.352-358- Abstract
Fluorescent molecularly imprinted polymers (MIPs) have received considerable attention for their promising applications in sensing, imaging and diagnostics. Different synthetic methods have been reported to prepare fluorescent MIPs. Here, one-pot polymerization method was developed to synthesize fluorescent MIP nanoparticles (NPs) bearing a suitable fluorescent label as the fluorescence acceptor. The MIP NPs can emit strong fluorescence based on fluorescence resonance energy transfer (FRET) when they bind to analytes acting as the fluorescence donor. The one-pot synthetic method is straightforward, less time-consuming and easy to optimize the loading of fluorescence acceptor. Additionally, a preliminary microfluidic reactor was designed... (More)
Fluorescent molecularly imprinted polymers (MIPs) have received considerable attention for their promising applications in sensing, imaging and diagnostics. Different synthetic methods have been reported to prepare fluorescent MIPs. Here, one-pot polymerization method was developed to synthesize fluorescent MIP nanoparticles (NPs) bearing a suitable fluorescent label as the fluorescence acceptor. The MIP NPs can emit strong fluorescence based on fluorescence resonance energy transfer (FRET) when they bind to analytes acting as the fluorescence donor. The one-pot synthetic method is straightforward, less time-consuming and easy to optimize the loading of fluorescence acceptor. Additionally, a preliminary microfluidic reactor was designed for preparing such fluorescent MIP NPs with more uniform size in a continuous process for the first time. The fluorescent MIP NPs can be used for selective detection of the analytical target in a FRET-based turn-on fluorescence assay which is easy to carry out with no tedious separation steps.
(Less)
- author
- Li, Qianjin LU ; Jiang, Lingdong LU ; Kamra, Tripta LU and Ye, Lei LU
- organization
- publishing date
- 2018-02-28
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Fluorescence resonance energy transfer, Molecularly imprinted polymer, One-pot synthesis
- in
- Polymer
- volume
- 138
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85041476980
- ISSN
- 0032-3861
- DOI
- 10.1016/j.polymer.2018.01.086
- language
- English
- LU publication?
- yes
- id
- da0b2303-6bdc-422f-a504-e802c72556fa
- date added to LUP
- 2018-02-20 13:44:26
- date last changed
- 2022-04-25 05:38:52
@article{da0b2303-6bdc-422f-a504-e802c72556fa, abstract = {{<p>Fluorescent molecularly imprinted polymers (MIPs) have received considerable attention for their promising applications in sensing, imaging and diagnostics. Different synthetic methods have been reported to prepare fluorescent MIPs. Here, one-pot polymerization method was developed to synthesize fluorescent MIP nanoparticles (NPs) bearing a suitable fluorescent label as the fluorescence acceptor. The MIP NPs can emit strong fluorescence based on fluorescence resonance energy transfer (FRET) when they bind to analytes acting as the fluorescence donor. The one-pot synthetic method is straightforward, less time-consuming and easy to optimize the loading of fluorescence acceptor. Additionally, a preliminary microfluidic reactor was designed for preparing such fluorescent MIP NPs with more uniform size in a continuous process for the first time. The fluorescent MIP NPs can be used for selective detection of the analytical target in a FRET-based turn-on fluorescence assay which is easy to carry out with no tedious separation steps.</p>}}, author = {{Li, Qianjin and Jiang, Lingdong and Kamra, Tripta and Ye, Lei}}, issn = {{0032-3861}}, keywords = {{Fluorescence resonance energy transfer; Molecularly imprinted polymer; One-pot synthesis}}, language = {{eng}}, month = {{02}}, pages = {{352--358}}, publisher = {{Elsevier}}, series = {{Polymer}}, title = {{Synthesis of fluorescent molecularly imprinted nanoparticles for turn-on fluorescence assay using one-pot synthetic method and a preliminary microfluidic approach}}, url = {{http://dx.doi.org/10.1016/j.polymer.2018.01.086}}, doi = {{10.1016/j.polymer.2018.01.086}}, volume = {{138}}, year = {{2018}}, }