The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest
(2019) In Biomarkers 24(1). p.29-35- Abstract
Background: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA. Methods: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls. In the main trial, 167 unconscious survivors of OHCA from the Targeted Temperature Management (TTM) trial were included. Results: In the pilot trial, plasma miR-122-5p at admission after OHCA was 400-fold elevated compared to controls. In... (More)
Background: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA. Methods: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls. In the main trial, 167 unconscious survivors of OHCA from the Targeted Temperature Management (TTM) trial were included. Results: In the pilot trial, plasma miR-122-5p at admission after OHCA was 400-fold elevated compared to controls. In the main trial, plasma miR-122-5p at admission was independently associated with lactate and bystander cardiopulmonary resuscitation. miR-122-5p at admission was not associated with shock at admission (p = 0.14) or all-cause mortality (p = 0.35). Target temperature (33 °C vs 36 °C) was not associated with miR-122-5p levels at any time point. Conclusions: After OHCA, miR-122-5p demonstrated a marked acute increase in plasma and was independently associated with lactate and bystander resuscitation. However, miR-122-5p at admission was not associated with all-cause mortality or shock at admission.
(Less)
- author
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- bystander CPR, cardiac arrest, lactate, outcome, Plasma microRNA, shock
- in
- Biomarkers
- volume
- 24
- issue
- 1
- pages
- 29 - 35
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:30015516
- scopus:85052304532
- ISSN
- 1354-750X
- DOI
- 10.1080/1354750X.2018.1499804
- language
- English
- LU publication?
- yes
- id
- db7ac51f-2279-4afc-98d6-95ef838e2fe9
- date added to LUP
- 2018-10-04 11:03:05
- date last changed
- 2024-07-08 19:52:03
@article{db7ac51f-2279-4afc-98d6-95ef838e2fe9, abstract = {{<p>Background: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA. Methods: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls. In the main trial, 167 unconscious survivors of OHCA from the Targeted Temperature Management (TTM) trial were included. Results: In the pilot trial, plasma miR-122-5p at admission after OHCA was 400-fold elevated compared to controls. In the main trial, plasma miR-122-5p at admission was independently associated with lactate and bystander cardiopulmonary resuscitation. miR-122-5p at admission was not associated with shock at admission (p = 0.14) or all-cause mortality (p = 0.35). Target temperature (33 °C vs 36 °C) was not associated with miR-122-5p levels at any time point. Conclusions: After OHCA, miR-122-5p demonstrated a marked acute increase in plasma and was independently associated with lactate and bystander resuscitation. However, miR-122-5p at admission was not associated with all-cause mortality or shock at admission.</p>}}, author = {{Gilje, Patrik and Frydland, Martin and Bro-Jeppesen, John and Dankiewicz, Josef and Friberg, Hans and Rundgren, Malin and Devaux, Yvan and Stammet, Pascal and Al-Mashat, Mariam and Jögi, Jonas and Kjaergaard, Jesper and Hassager, Christian and Erlinge, David}}, issn = {{1354-750X}}, keywords = {{bystander CPR; cardiac arrest; lactate; outcome; Plasma microRNA; shock}}, language = {{eng}}, number = {{1}}, pages = {{29--35}}, publisher = {{Taylor & Francis}}, series = {{Biomarkers}}, title = {{The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest}}, url = {{http://dx.doi.org/10.1080/1354750X.2018.1499804}}, doi = {{10.1080/1354750X.2018.1499804}}, volume = {{24}}, year = {{2019}}, }