Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
(2019) In Nature Communications 10(1).- Abstract
- Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1,... (More)
- Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels. © 2019, The Author(s). (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/ddccdd28-505a-425f-bbb9-5250d5206f47
- author
- Kilpeläinen, Tuomas O ; V. Varga, Tibor LU ; Poveda, Alaitz LU ; Franks, Paul LU ; Rao, Dabeeru C. and Loos, Ruth J. F.
- author collaboration
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Communications
- volume
- 10
- issue
- 1
- article number
- 376
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:30670697
- scopus:85060388984
- ISSN
- 2041-1723
- DOI
- 10.1038/s41467-018-08008-w
- language
- English
- LU publication?
- yes
- additional info
- Export Date: 1 February 2019
- id
- ddccdd28-505a-425f-bbb9-5250d5206f47
- date added to LUP
- 2019-02-01 08:28:35
- date last changed
- 2022-04-25 20:38:50
@article{ddccdd28-505a-425f-bbb9-5250d5206f47, abstract = {{Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels. © 2019, The Author(s).}}, author = {{Kilpeläinen, Tuomas O and V. Varga, Tibor and Poveda, Alaitz and Franks, Paul and Rao, Dabeeru C. and Loos, Ruth J. F.}}, issn = {{2041-1723}}, language = {{eng}}, number = {{1}}, publisher = {{Nature Publishing Group}}, series = {{Nature Communications}}, title = {{Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity}}, url = {{http://dx.doi.org/10.1038/s41467-018-08008-w}}, doi = {{10.1038/s41467-018-08008-w}}, volume = {{10}}, year = {{2019}}, }