Risks of breast, endometrial, and ovarian cancers after twin births
(2007) In Endocrine-Related Cancer 14(3). p.11-703- Abstract
The concentrations of endogenous hormones differ between women with twin and singleton births, with a possible influence on the risk of cancer. We used the nationwide Swedish Family-Cancer Database, including 30,409 women with a twin birth, to examine the subsequent risks of breast, endometrial, and ovarian cancers. Relative risks (RRs) were calculated in a log-linear Poisson regression model of person-years as offset. Cancer data were retrieved from the Swedish Cancer Registry; a total of 1010, 210, and 174 women were diagnosed with breast, endometrial, and ovarian cancers respectively, after a twin birth. A significant decrease in the risk of breast cancer was noted among women with a twin birth compared with women with a singleton... (More)
The concentrations of endogenous hormones differ between women with twin and singleton births, with a possible influence on the risk of cancer. We used the nationwide Swedish Family-Cancer Database, including 30,409 women with a twin birth, to examine the subsequent risks of breast, endometrial, and ovarian cancers. Relative risks (RRs) were calculated in a log-linear Poisson regression model of person-years as offset. Cancer data were retrieved from the Swedish Cancer Registry; a total of 1010, 210, and 174 women were diagnosed with breast, endometrial, and ovarian cancers respectively, after a twin birth. A significant decrease in the risk of breast cancer was noted among women with a twin birth compared with women with a singleton birth (RR 0.85, 95% confidence interval (CI) 0.74-0.98). The protective effects were observed throughout the intervals after last pregnancy and they were strongest shortly after the last pregnancy in women who delivered a twin birth before 30 years of age. Twin birth did not change the risk of endometrial cancer (1.08, 95% CI 0.79-1.47) but the RR was increased for women with the number of pregnancies > or =4 (1.39, 95% CI 1.11-1.76). The RR for ovarian cancer was 0.95 (95% CI 0.79-1.15). Our study showed that twin births significantly reduced the subsequent risk of breast cancer. However, the associations of twin births with endometrial and ovarian cancers were not substantial.
(Less)
- author
- Ji, Jianguang LU ; Försti, Asta LU ; Sundquist, Jan LU and Hemminki, Kari LU
- publishing date
- 2007-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adolescent, Adult, Age Factors, Breast Neoplasms/epidemiology, Cohort Studies, Databases, Factual, Endometrial Neoplasms/epidemiology, Female, Gravidity, Humans, Middle Aged, Ovarian Neoplasms/epidemiology, Pregnancy, Pregnancy, Multiple, Risk Factors, Twins
- in
- Endocrine-Related Cancer
- volume
- 14
- issue
- 3
- pages
- 11 - 703
- publisher
- Society for Endocrinology
- external identifiers
-
- pmid:17914100
- scopus:35948956748
- ISSN
- 1351-0088
- DOI
- 10.1677/ERC-07-0088
- language
- English
- LU publication?
- no
- id
- e0108e7f-b286-47a8-b557-6d1ac23583cd
- date added to LUP
- 2019-01-30 10:51:47
- date last changed
- 2024-09-03 11:31:49
@article{e0108e7f-b286-47a8-b557-6d1ac23583cd, abstract = {{<p>The concentrations of endogenous hormones differ between women with twin and singleton births, with a possible influence on the risk of cancer. We used the nationwide Swedish Family-Cancer Database, including 30,409 women with a twin birth, to examine the subsequent risks of breast, endometrial, and ovarian cancers. Relative risks (RRs) were calculated in a log-linear Poisson regression model of person-years as offset. Cancer data were retrieved from the Swedish Cancer Registry; a total of 1010, 210, and 174 women were diagnosed with breast, endometrial, and ovarian cancers respectively, after a twin birth. A significant decrease in the risk of breast cancer was noted among women with a twin birth compared with women with a singleton birth (RR 0.85, 95% confidence interval (CI) 0.74-0.98). The protective effects were observed throughout the intervals after last pregnancy and they were strongest shortly after the last pregnancy in women who delivered a twin birth before 30 years of age. Twin birth did not change the risk of endometrial cancer (1.08, 95% CI 0.79-1.47) but the RR was increased for women with the number of pregnancies > or =4 (1.39, 95% CI 1.11-1.76). The RR for ovarian cancer was 0.95 (95% CI 0.79-1.15). Our study showed that twin births significantly reduced the subsequent risk of breast cancer. However, the associations of twin births with endometrial and ovarian cancers were not substantial.</p>}}, author = {{Ji, Jianguang and Försti, Asta and Sundquist, Jan and Hemminki, Kari}}, issn = {{1351-0088}}, keywords = {{Adolescent; Adult; Age Factors; Breast Neoplasms/epidemiology; Cohort Studies; Databases, Factual; Endometrial Neoplasms/epidemiology; Female; Gravidity; Humans; Middle Aged; Ovarian Neoplasms/epidemiology; Pregnancy; Pregnancy, Multiple; Risk Factors; Twins}}, language = {{eng}}, number = {{3}}, pages = {{11--703}}, publisher = {{Society for Endocrinology}}, series = {{Endocrine-Related Cancer}}, title = {{Risks of breast, endometrial, and ovarian cancers after twin births}}, url = {{http://dx.doi.org/10.1677/ERC-07-0088}}, doi = {{10.1677/ERC-07-0088}}, volume = {{14}}, year = {{2007}}, }