Progress and outlook of inorganic nanoparticles for delivery of nucleic acid sequences related to orthopedic pathologies : A review
Wagner, Darcy E. LU
and Bhaduri, Sarit B.
(2012)
In Tissue Engineering - Part B: Reviews
18(1).
p.1-14
- Abstract
The anticipated growth in the aging population will drastically increase medical needs of society; of which, one of the largest components will undoubtedly be from orthopedic-related pathologies. There are several proposed solutions being investigated to cost-effectively prepare for the future-pharmaceuticals, implant devices, cell and gene therapies, or some combination thereof. Gene therapy is one of the more promising possibilities because it seeks to correct the root of the problem, thereby minimizing treatment duration and cost. Currently, viral vectors have shown the highest efficacies, but immunological concerns remain. Nonviral methods show reduced immune responses but are regarded as less efficient. The nonviral paradigms... (More)
The anticipated growth in the aging population will drastically increase medical needs of society; of which, one of the largest components will undoubtedly be from orthopedic-related pathologies. There are several proposed solutions being investigated to cost-effectively prepare for the future-pharmaceuticals, implant devices, cell and gene therapies, or some combination thereof. Gene therapy is one of the more promising possibilities because it seeks to correct the root of the problem, thereby minimizing treatment duration and cost. Currently, viral vectors have shown the highest efficacies, but immunological concerns remain. Nonviral methods show reduced immune responses but are regarded as less efficient. The nonviral paradigms consist of mechanical and chemical approaches. While organic-based materials have been used more frequently in particle-based methods, inorganic materials capable of delivery have distinct advantages, especially advantageous in orthopedic applications. The inorganic gene therapy field is highly interdisciplinary in nature, and requires assimilation of knowledge across the broad fields of cell biology, biochemistry, molecular genetics, materials science, and clinical medicine. This review provides an overview of the role each area plays in orthopedic gene therapy as well as possible future directions for the field.
(Less)
- author
- Wagner, Darcy E.
LU
and Bhaduri, Sarit B.
- publishing date
- 2012-02-01
- type
- Contribution to journal
- publication status
- published
- in
- Tissue Engineering - Part B: Reviews
- volume
- 18
- issue
- 1
- pages
- 14 pages
- publisher
- Mary Ann Liebert, Inc.
- external identifiers
-
- scopus:84856151412
- ISSN
- 1937-3368
- DOI
- 10.1089/ten.teb.2011.0081
- language
- English
- LU publication?
- no
- id
- e2caaa3a-b468-41d5-8043-138a52f799da
- date added to LUP
- 2017-08-15 15:13:53
- date last changed
- 2022-03-01 23:46:41
@article{e2caaa3a-b468-41d5-8043-138a52f799da,
abstract = {{<p>The anticipated growth in the aging population will drastically increase medical needs of society; of which, one of the largest components will undoubtedly be from orthopedic-related pathologies. There are several proposed solutions being investigated to cost-effectively prepare for the future-pharmaceuticals, implant devices, cell and gene therapies, or some combination thereof. Gene therapy is one of the more promising possibilities because it seeks to correct the root of the problem, thereby minimizing treatment duration and cost. Currently, viral vectors have shown the highest efficacies, but immunological concerns remain. Nonviral methods show reduced immune responses but are regarded as less efficient. The nonviral paradigms consist of mechanical and chemical approaches. While organic-based materials have been used more frequently in particle-based methods, inorganic materials capable of delivery have distinct advantages, especially advantageous in orthopedic applications. The inorganic gene therapy field is highly interdisciplinary in nature, and requires assimilation of knowledge across the broad fields of cell biology, biochemistry, molecular genetics, materials science, and clinical medicine. This review provides an overview of the role each area plays in orthopedic gene therapy as well as possible future directions for the field.</p>}},
author = {{Wagner, Darcy E. and Bhaduri, Sarit B.}},
issn = {{1937-3368}},
language = {{eng}},
month = {{02}},
number = {{1}},
pages = {{1--14}},
publisher = {{Mary Ann Liebert, Inc.}},
series = {{Tissue Engineering - Part B: Reviews}},
title = {{Progress and outlook of inorganic nanoparticles for delivery of nucleic acid sequences related to orthopedic pathologies : A review}},
url = {{http://dx.doi.org/10.1089/ten.teb.2011.0081}},
doi = {{10.1089/ten.teb.2011.0081}},
volume = {{18}},
year = {{2012}},
}