Detection of HPV mRNA in Self-collected Vaginal Samples Among Women at 69-70 Years of Age
(2019) In Anticancer research 39(1). p.381-386- Abstract
BACKGROUND/AIM: Cervical cancer is associated with poorer diagnosis among the elderly and pap-smear screening has a lower sensitivity. Self-sampling for detection of high-risk human papillomavirus (hr-HPV) may be an alternative screening method. The aim of this study was to analyze the response rate to vaginal HPV self-sampling and the HPV mRNA prevalence among women 69-70 years. MATERIALS AND METHODS: An HPV self-sampling kit was sent to 1,000 women 69-70 years whom had not taken a cervical smear in ≥5 years. The samples were analyzed by the Aptima HPV mRNA assay. HPV-positive women were recalled for a follow-up examination. RESULTS: The self-sample response rate was 43.3%. The HPV mRNA prevalence was 6.2%. All HPV-positive women... (More)
BACKGROUND/AIM: Cervical cancer is associated with poorer diagnosis among the elderly and pap-smear screening has a lower sensitivity. Self-sampling for detection of high-risk human papillomavirus (hr-HPV) may be an alternative screening method. The aim of this study was to analyze the response rate to vaginal HPV self-sampling and the HPV mRNA prevalence among women 69-70 years. MATERIALS AND METHODS: An HPV self-sampling kit was sent to 1,000 women 69-70 years whom had not taken a cervical smear in ≥5 years. The samples were analyzed by the Aptima HPV mRNA assay. HPV-positive women were recalled for a follow-up examination. RESULTS: The self-sample response rate was 43.3%. The HPV mRNA prevalence was 6.2%. All HPV-positive women attended follow-up. CONCLUSION: HPV self-sampling was accepted among older women. Although the HPV mRNA prevalence was 6.2%, no high-grade cytological abnormalities were found. Larger studies are needed to elucidate hr-HPV self-sampling as a tool to identify older women at risk of cervical cancer.
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- author
- Ernstson, Avalon LU ; Asciutto, Katrin Christine LU ; Sturesson, Johan ; Norén, Jonas ; Forslund, Ola LU and Borgfeldt, Christer LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cervical cancer, human papillomavirus, postmenopausal women, self-sampling
- in
- Anticancer research
- volume
- 39
- issue
- 1
- pages
- 6 pages
- publisher
- International Institute of Cancer Research
- external identifiers
-
- pmid:30591484
- scopus:85059227657
- ISSN
- 1791-7530
- DOI
- 10.21873/anticanres.13123
- language
- English
- LU publication?
- yes
- id
- e41977d2-910b-4115-9bf1-74ad97ddcaf4
- date added to LUP
- 2019-01-11 09:10:12
- date last changed
- 2024-07-23 06:59:40
@article{e41977d2-910b-4115-9bf1-74ad97ddcaf4, abstract = {{<p>BACKGROUND/AIM: Cervical cancer is associated with poorer diagnosis among the elderly and pap-smear screening has a lower sensitivity. Self-sampling for detection of high-risk human papillomavirus (hr-HPV) may be an alternative screening method. The aim of this study was to analyze the response rate to vaginal HPV self-sampling and the HPV mRNA prevalence among women 69-70 years. MATERIALS AND METHODS: An HPV self-sampling kit was sent to 1,000 women 69-70 years whom had not taken a cervical smear in ≥5 years. The samples were analyzed by the Aptima HPV mRNA assay. HPV-positive women were recalled for a follow-up examination. RESULTS: The self-sample response rate was 43.3%. The HPV mRNA prevalence was 6.2%. All HPV-positive women attended follow-up. CONCLUSION: HPV self-sampling was accepted among older women. Although the HPV mRNA prevalence was 6.2%, no high-grade cytological abnormalities were found. Larger studies are needed to elucidate hr-HPV self-sampling as a tool to identify older women at risk of cervical cancer.</p>}}, author = {{Ernstson, Avalon and Asciutto, Katrin Christine and Sturesson, Johan and Norén, Jonas and Forslund, Ola and Borgfeldt, Christer}}, issn = {{1791-7530}}, keywords = {{Cervical cancer; human papillomavirus; postmenopausal women; self-sampling}}, language = {{eng}}, number = {{1}}, pages = {{381--386}}, publisher = {{International Institute of Cancer Research}}, series = {{Anticancer research}}, title = {{Detection of HPV mRNA in Self-collected Vaginal Samples Among Women at 69-70 Years of Age}}, url = {{http://dx.doi.org/10.21873/anticanres.13123}}, doi = {{10.21873/anticanres.13123}}, volume = {{39}}, year = {{2019}}, }