Deposition efficiency of inhaled particles (15-5000 nm) related to breathing pattern and lung function : An experimental study in healthy children and adults
Rissler, Jenny LU ; Gudmundsson, Anders LU ; Nicklasson, Hanna LU ; Swietlicki, Erik LU
; Wollmer, Per
LU
and Löndahl, Jakob
LU
(2017)
In Particle and Fibre Toxicology
14(1).
- Abstract
Background: Exposure to airborne particles has a major impact on global health. The probability of these particles to deposit in the respiratory tract during breathing is essential for their toxic effects. Observations have shown that there is a substantial variability in deposition between subjects, not only due to respiratory diseases, but also among individuals with healthy lungs. The factors determining this variability are, however, not fully understood. Method: In this study we experimentally investigate factors that determine individual differences in the respiratory tract depositions of inhaled particles for healthy subjects at relaxed breathing. The study covers particles of diameters 15-5000 nm and includes 67 subjects aged... (More)
Background: Exposure to airborne particles has a major impact on global health. The probability of these particles to deposit in the respiratory tract during breathing is essential for their toxic effects. Observations have shown that there is a substantial variability in deposition between subjects, not only due to respiratory diseases, but also among individuals with healthy lungs. The factors determining this variability are, however, not fully understood. Method: In this study we experimentally investigate factors that determine individual differences in the respiratory tract depositions of inhaled particles for healthy subjects at relaxed breathing. The study covers particles of diameters 15-5000 nm and includes 67 subjects aged 7-70 years. A comprehensive examination of lung function was performed for all subjects. Principal component analyses and multiple regression analyses were used to explore the relationships between subject characteristics and particle deposition. Results: A large individual variability in respiratory tract deposition efficiency was found. Individuals with high deposition of a certain particle size generally had high deposition for all particles <3500 nm. The individual variability was explained by two factors: breathing pattern, and lung structural and functional properties. The most important predictors were found to be breathing frequency and anatomical airway dead space. We also present a linear regression model describing the deposition based on four variables: tidal volume, breathing frequency, anatomical dead space and resistance of the respiratory system (the latter measured with impulse oscillometry). Conclusions: To understand why some individuals are more susceptible to airborne particles we must understand, and take into account, the individual variability in the probability of particles to deposit in the respiratory tract by considering not only breathing patterns but also adequate measures of relevant structural and functional properties.
(Less)
- author
- Rissler, Jenny
LU
; Gudmundsson, Anders
LU
; Nicklasson, Hanna
LU
; Swietlicki, Erik
LU
; Wollmer, Per
LU
and Löndahl, Jakob
LU
- organization
- publishing date
- 2017-04-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aerosols, Airborne particles, Airway dead space, Individual variability, Inhalation, Lung dose, NanoSafety, Particle lung deposition, Respiratory tract deposition
- in
- Particle and Fibre Toxicology
- volume
- 14
- issue
- 1
- article number
- 10
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:28388961
- wos:000398513900001
- scopus:85018416270
- ISSN
- 1743-8977
- DOI
- 10.1186/s12989-017-0190-8
- language
- English
- LU publication?
- yes
- id
- ebff351d-30e2-4466-9a5a-0092fb7d2781
- date added to LUP
- 2017-05-19 08:39:04
- date last changed
- 2024-04-14 11:49:57
@article{ebff351d-30e2-4466-9a5a-0092fb7d2781,
abstract = {{<p>Background: Exposure to airborne particles has a major impact on global health. The probability of these particles to deposit in the respiratory tract during breathing is essential for their toxic effects. Observations have shown that there is a substantial variability in deposition between subjects, not only due to respiratory diseases, but also among individuals with healthy lungs. The factors determining this variability are, however, not fully understood. Method: In this study we experimentally investigate factors that determine individual differences in the respiratory tract depositions of inhaled particles for healthy subjects at relaxed breathing. The study covers particles of diameters 15-5000 nm and includes 67 subjects aged 7-70 years. A comprehensive examination of lung function was performed for all subjects. Principal component analyses and multiple regression analyses were used to explore the relationships between subject characteristics and particle deposition. Results: A large individual variability in respiratory tract deposition efficiency was found. Individuals with high deposition of a certain particle size generally had high deposition for all particles <3500 nm. The individual variability was explained by two factors: breathing pattern, and lung structural and functional properties. The most important predictors were found to be breathing frequency and anatomical airway dead space. We also present a linear regression model describing the deposition based on four variables: tidal volume, breathing frequency, anatomical dead space and resistance of the respiratory system (the latter measured with impulse oscillometry). Conclusions: To understand why some individuals are more susceptible to airborne particles we must understand, and take into account, the individual variability in the probability of particles to deposit in the respiratory tract by considering not only breathing patterns but also adequate measures of relevant structural and functional properties.</p>}},
author = {{Rissler, Jenny and Gudmundsson, Anders and Nicklasson, Hanna and Swietlicki, Erik and Wollmer, Per and Löndahl, Jakob}},
issn = {{1743-8977}},
keywords = {{Aerosols; Airborne particles; Airway dead space; Individual variability; Inhalation; Lung dose; NanoSafety; Particle lung deposition; Respiratory tract deposition}},
language = {{eng}},
month = {{04}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{Particle and Fibre Toxicology}},
title = {{Deposition efficiency of inhaled particles (15-5000 nm) related to breathing pattern and lung function : An experimental study in healthy children and adults}},
url = {{http://dx.doi.org/10.1186/s12989-017-0190-8}},
doi = {{10.1186/s12989-017-0190-8}},
volume = {{14}},
year = {{2017}},
}