Valid Exposure Protocols Needed in Magnetic Resonance Imaging Genotoxic Research
(2020) In Bioelectromagnetics 41(3). p.247-257- Abstract
Several in vitro and in vivo studies have investigated if a magnetic resonance imaging (MRI) examination can cause DNA damage in human blood cells. However, the electromagnetic field (EMF) exposure that the cells received in the MR scanner was not sufficiently described. The first studies looking into this could be regarded as hypothesis-generating studies. However, for further exploration into the role of MRI exposure on DNA integrity, the exposure itself cannot be ignored. The lack of sufficient method descriptions makes the early experiments difficult, if not impossible, to repeat. The golden rule in all experimental work is that a study should be repeatable by someone with the right knowledge and equipment, and this is simply not... (More)
Several in vitro and in vivo studies have investigated if a magnetic resonance imaging (MRI) examination can cause DNA damage in human blood cells. However, the electromagnetic field (EMF) exposure that the cells received in the MR scanner was not sufficiently described. The first studies looking into this could be regarded as hypothesis-generating studies. However, for further exploration into the role of MRI exposure on DNA integrity, the exposure itself cannot be ignored. The lack of sufficient method descriptions makes the early experiments difficult, if not impossible, to repeat. The golden rule in all experimental work is that a study should be repeatable by someone with the right knowledge and equipment, and this is simply not the case with many of the recent studies on MRI and genotoxicity. Here we discuss what is lacking in previous studies, and how we think the next generation of in vitro and in vivo studies on MRI and genotoxicity should be performed. Bioelectromagnetics.
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- author
- Wilén, Jonna ; Olsrud, Johan LU ; Frankel, Jennifer and Hansson Mild, Kjell
- organization
- publishing date
- 2020-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- DNA, genotoxicity, isocenter, magnetic field, pulse sequence
- in
- Bioelectromagnetics
- volume
- 41
- issue
- 3
- pages
- 11 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85081679643
- pmid:32157722
- ISSN
- 0197-8462
- DOI
- 10.1002/bem.22257
- language
- English
- LU publication?
- yes
- id
- ee3f073d-e4b0-49b2-8423-535b8640cdd0
- date added to LUP
- 2020-03-30 17:00:27
- date last changed
- 2024-09-18 21:31:39
@article{ee3f073d-e4b0-49b2-8423-535b8640cdd0, abstract = {{<p>Several in vitro and in vivo studies have investigated if a magnetic resonance imaging (MRI) examination can cause DNA damage in human blood cells. However, the electromagnetic field (EMF) exposure that the cells received in the MR scanner was not sufficiently described. The first studies looking into this could be regarded as hypothesis-generating studies. However, for further exploration into the role of MRI exposure on DNA integrity, the exposure itself cannot be ignored. The lack of sufficient method descriptions makes the early experiments difficult, if not impossible, to repeat. The golden rule in all experimental work is that a study should be repeatable by someone with the right knowledge and equipment, and this is simply not the case with many of the recent studies on MRI and genotoxicity. Here we discuss what is lacking in previous studies, and how we think the next generation of in vitro and in vivo studies on MRI and genotoxicity should be performed. Bioelectromagnetics.</p>}}, author = {{Wilén, Jonna and Olsrud, Johan and Frankel, Jennifer and Hansson Mild, Kjell}}, issn = {{0197-8462}}, keywords = {{DNA; genotoxicity; isocenter; magnetic field; pulse sequence}}, language = {{eng}}, number = {{3}}, pages = {{247--257}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Bioelectromagnetics}}, title = {{Valid Exposure Protocols Needed in Magnetic Resonance Imaging Genotoxic Research}}, url = {{http://dx.doi.org/10.1002/bem.22257}}, doi = {{10.1002/bem.22257}}, volume = {{41}}, year = {{2020}}, }