Evidence of association between type 1 diabetes and exposure to enterovirus in Cuban children and adolescents
(2013) In MEDICC review 15(1). p.29-32- Abstract
A possible etiologic role of enteroviruses for type 1 diabetes has been researched for 40 years, but evidence to date is inconclusive. This article summarizes new evidence from Cuban research supporting a role for enteroviruses, both in preclinical stages of autoimmune reactions against pancreatic β cells and at clinical onset, in a population with low type 1 diabetes incidence. Possible pathogenetic mechanisms are also discussed, such as acute cytolytic damage and molecular mimicry. Although direct causal effects of enteroviruses in type 1 diabetes are difficult to demonstrate, arguments supporting their role in type 1 diabetes pathogenesis should not be ignored; and confirmation could contribute to development of more effective... (More)
A possible etiologic role of enteroviruses for type 1 diabetes has been researched for 40 years, but evidence to date is inconclusive. This article summarizes new evidence from Cuban research supporting a role for enteroviruses, both in preclinical stages of autoimmune reactions against pancreatic β cells and at clinical onset, in a population with low type 1 diabetes incidence. Possible pathogenetic mechanisms are also discussed, such as acute cytolytic damage and molecular mimicry. Although direct causal effects of enteroviruses in type 1 diabetes are difficult to demonstrate, arguments supporting their role in type 1 diabetes pathogenesis should not be ignored; and confirmation could contribute to development of more effective preventive strategies.
(Less)
- author
- Sarmiento, Luis ; Cubas-Dueñas, Ileana LU and Cabrera-Rode, Eduardo
- publishing date
- 2013-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adolescent, Antibodies, Viral/immunology, Autoantibodies/immunology, Biomedical Research, Child, Cuba, Diabetes Mellitus, Type 1/immunology, Enterovirus/immunology, Humans, Insulin-Secreting Cells/immunology
- in
- MEDICC review
- volume
- 15
- issue
- 1
- pages
- 4 pages
- publisher
- MEDICC Medical Education Cooperation with Cuba
- external identifiers
-
- pmid:23396239
- scopus:84873348115
- ISSN
- 1527-3172
- DOI
- 10.1590/S1555-79602013000100007
- language
- English
- LU publication?
- no
- id
- f06e9c4d-f797-4592-a731-210b0e05648e
- date added to LUP
- 2019-07-08 14:24:54
- date last changed
- 2024-04-30 17:27:40
@article{f06e9c4d-f797-4592-a731-210b0e05648e, abstract = {{<p>A possible etiologic role of enteroviruses for type 1 diabetes has been researched for 40 years, but evidence to date is inconclusive. This article summarizes new evidence from Cuban research supporting a role for enteroviruses, both in preclinical stages of autoimmune reactions against pancreatic β cells and at clinical onset, in a population with low type 1 diabetes incidence. Possible pathogenetic mechanisms are also discussed, such as acute cytolytic damage and molecular mimicry. Although direct causal effects of enteroviruses in type 1 diabetes are difficult to demonstrate, arguments supporting their role in type 1 diabetes pathogenesis should not be ignored; and confirmation could contribute to development of more effective preventive strategies.</p>}}, author = {{Sarmiento, Luis and Cubas-Dueñas, Ileana and Cabrera-Rode, Eduardo}}, issn = {{1527-3172}}, keywords = {{Adolescent; Antibodies, Viral/immunology; Autoantibodies/immunology; Biomedical Research; Child; Cuba; Diabetes Mellitus, Type 1/immunology; Enterovirus/immunology; Humans; Insulin-Secreting Cells/immunology}}, language = {{eng}}, number = {{1}}, pages = {{29--32}}, publisher = {{MEDICC Medical Education Cooperation with Cuba}}, series = {{MEDICC review}}, title = {{Evidence of association between type 1 diabetes and exposure to enterovirus in Cuban children and adolescents}}, url = {{http://dx.doi.org/10.1590/S1555-79602013000100007}}, doi = {{10.1590/S1555-79602013000100007}}, volume = {{15}}, year = {{2013}}, }