Infiltration of γδ T cells, IL-17 + T cells and FoxP3 + T cells in human breast cancer
Allaoui, Roni LU ; Hagerling, Catharina LU ; Desmond, Eva ; Warfvinge, Carl Fredrik LU ; Jirström, Karin LU
and Leandersson, Karin
LU
(2017)
In Cancer Biomarkers
20(4).
p.395-409
- Abstract
BACKGROUND: Tumor-infiltrating lymphocytes (TILs) have a strong prognostic value in various forms of cancers. These data often refer to use of the pan-T cell marker CD3, or the cytotoxic T lymphocyte marker CD8α. However, T cells are a heterogeneous group of cells with a wide array of effector mechanisms ranging from immunosuppression to cytotoxicity. OBJECTIVE: In this study we have investigated the prognostic effects of some unconventional T cell subtypes in breast cancer; γδ T cells, IL-17+ T cells and FoxP3+ T cells (Tregs) in relation to the conventional CD3 and CD8α T cell markers. METHODS: This was done using immunohistochemistry on a human breast cancer tissue microarray consisting of 498 consecutive cases of primary breast... (More)
BACKGROUND: Tumor-infiltrating lymphocytes (TILs) have a strong prognostic value in various forms of cancers. These data often refer to use of the pan-T cell marker CD3, or the cytotoxic T lymphocyte marker CD8α. However, T cells are a heterogeneous group of cells with a wide array of effector mechanisms ranging from immunosuppression to cytotoxicity. OBJECTIVE: In this study we have investigated the prognostic effects of some unconventional T cell subtypes in breast cancer; γδ T cells, IL-17+ T cells and FoxP3+ T cells (Tregs) in relation to the conventional CD3 and CD8α T cell markers. METHODS: This was done using immunohistochemistry on a human breast cancer tissue microarray consisting of 498 consecutive cases of primary breast cancer. RESULTS: Infiltration of γδ T cells and T cell infiltration in general (CD3), correlated with a good prognosis, while Treg infiltration with a worse. Infiltration of γδ T cells was associated with a significantly improved clinical outcome in all breast cancer subtypes except triple negative tumors. Only infiltration of either CD3+ or CD8α+ cells was independently associated with better prognosis for all breast cancer patients. CONCLUSIONS: This study sheds further light on the prognostic impact of various T cell subtypes in breast cancer.
(Less)
- author
- Allaoui, Roni
LU
; Hagerling, Catharina
LU
; Desmond, Eva
; Warfvinge, Carl Fredrik
LU
; Jirström, Karin
LU
and Leandersson, Karin
LU
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Breast cancer, prognosis, T lymphocytes, TILs, unconventional T cells
- in
- Cancer Biomarkers
- volume
- 20
- issue
- 4
- pages
- 15 pages
- publisher
- IOS Press
- external identifiers
-
- pmid:29060923
- scopus:85039164242
- ISSN
- 1574-0153
- DOI
- 10.3233/CBM-170026
- language
- English
- LU publication?
- yes
- id
- f0d850e9-69c3-49b1-85a2-288d9eebf374
- date added to LUP
- 2018-01-22 18:08:38
- date last changed
- 2024-04-15 02:10:49
@article{f0d850e9-69c3-49b1-85a2-288d9eebf374,
abstract = {{<p>BACKGROUND: Tumor-infiltrating lymphocytes (TILs) have a strong prognostic value in various forms of cancers. These data often refer to use of the pan-T cell marker CD3, or the cytotoxic T lymphocyte marker CD8α. However, T cells are a heterogeneous group of cells with a wide array of effector mechanisms ranging from immunosuppression to cytotoxicity. OBJECTIVE: In this study we have investigated the prognostic effects of some unconventional T cell subtypes in breast cancer; γδ T cells, IL-17+ T cells and FoxP3+ T cells (Tregs) in relation to the conventional CD3 and CD8α T cell markers. METHODS: This was done using immunohistochemistry on a human breast cancer tissue microarray consisting of 498 consecutive cases of primary breast cancer. RESULTS: Infiltration of γδ T cells and T cell infiltration in general (CD3), correlated with a good prognosis, while Treg infiltration with a worse. Infiltration of γδ T cells was associated with a significantly improved clinical outcome in all breast cancer subtypes except triple negative tumors. Only infiltration of either CD3+ or CD8α+ cells was independently associated with better prognosis for all breast cancer patients. CONCLUSIONS: This study sheds further light on the prognostic impact of various T cell subtypes in breast cancer.</p>}},
author = {{Allaoui, Roni and Hagerling, Catharina and Desmond, Eva and Warfvinge, Carl Fredrik and Jirström, Karin and Leandersson, Karin}},
issn = {{1574-0153}},
keywords = {{Breast cancer; prognosis; T lymphocytes; TILs; unconventional T cells}},
language = {{eng}},
number = {{4}},
pages = {{395--409}},
publisher = {{IOS Press}},
series = {{Cancer Biomarkers}},
title = {{Infiltration of γδ T cells, IL-17 + T cells and FoxP3 + T cells in human breast cancer}},
url = {{http://dx.doi.org/10.3233/CBM-170026}},
doi = {{10.3233/CBM-170026}},
volume = {{20}},
year = {{2017}},
}