The role of topical timolol in the treatment of infantile hemangiomas : A systematic review and meta-analysis
(2017) In Acta Dermato-Venereologica 97(10). p.1167-1171- Abstract
To date the efficacy and safety of topical timolol in the treatment of infantile hemangioma has not been reviewed and analysed systematically. We collated all published data on the efficacy and safety of topical timolol in the treatment of infantile hemangioma. A total of 31 studies with 691 patients were included. The fixed effects pooled estimate of the response rate defined as any improvement from baseline of infantile hemangioma after treatment with topical timolol was significant (RR = 8.96; 95% CI 5.07–15.47; heterogeneity test p = 0.99), and the treatment was overall well tolerated. However, the quality of evidence was low to moderate. Topical timolol is an effective treatment for small infantile hemangioma, with no significant... (More)
To date the efficacy and safety of topical timolol in the treatment of infantile hemangioma has not been reviewed and analysed systematically. We collated all published data on the efficacy and safety of topical timolol in the treatment of infantile hemangioma. A total of 31 studies with 691 patients were included. The fixed effects pooled estimate of the response rate defined as any improvement from baseline of infantile hemangioma after treatment with topical timolol was significant (RR = 8.96; 95% CI 5.07–15.47; heterogeneity test p = 0.99), and the treatment was overall well tolerated. However, the quality of evidence was low to moderate. Topical timolol is an effective treatment for small infantile hemangioma, with no significant adverse effects noted. However, there is still a need for adequately powered randomised controlled trials.
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- author
- Khan, Maham ; Boyce, Aaron ; Prieto-Merino, David ; Svensson, Åke LU ; Wedgeworth, Emma and Flohr, Carsten
- organization
- publishing date
- 2017-11-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Beta-blocker, Infantile hemangioma, Timolol
- in
- Acta Dermato-Venereologica
- volume
- 97
- issue
- 10
- pages
- 5 pages
- publisher
- Medical Journals Limited
- external identifiers
-
- pmid:28421234
- scopus:85032669123
- ISSN
- 0001-5555
- DOI
- 10.2340/00015555-2681
- language
- English
- LU publication?
- yes
- id
- f23ee1b4-fa30-4fc8-bbab-f8bf72c6cab2
- date added to LUP
- 2017-11-22 12:47:20
- date last changed
- 2024-04-29 23:17:44
@article{f23ee1b4-fa30-4fc8-bbab-f8bf72c6cab2,
abstract = {{<p>To date the efficacy and safety of topical timolol in the treatment of infantile hemangioma has not been reviewed and analysed systematically. We collated all published data on the efficacy and safety of topical timolol in the treatment of infantile hemangioma. A total of 31 studies with 691 patients were included. The fixed effects pooled estimate of the response rate defined as any improvement from baseline of infantile hemangioma after treatment with topical timolol was significant (RR = 8.96; 95% CI 5.07–15.47; heterogeneity test p = 0.99), and the treatment was overall well tolerated. However, the quality of evidence was low to moderate. Topical timolol is an effective treatment for small infantile hemangioma, with no significant adverse effects noted. However, there is still a need for adequately powered randomised controlled trials.</p>}},
author = {{Khan, Maham and Boyce, Aaron and Prieto-Merino, David and Svensson, Åke and Wedgeworth, Emma and Flohr, Carsten}},
issn = {{0001-5555}},
keywords = {{Beta-blocker; Infantile hemangioma; Timolol}},
language = {{eng}},
month = {{11}},
number = {{10}},
pages = {{1167--1171}},
publisher = {{Medical Journals Limited}},
series = {{Acta Dermato-Venereologica}},
title = {{The role of topical timolol in the treatment of infantile hemangiomas : A systematic review and meta-analysis}},
url = {{http://dx.doi.org/10.2340/00015555-2681}},
doi = {{10.2340/00015555-2681}},
volume = {{97}},
year = {{2017}},
}