NDDVD : an integrated and manually curated Neurodegenerative Diseases Variation Database
(2018) In Database: the journal of biological databases and curation 2018.- Abstract
Neurodegenerative diseases (NDDs) are associated with genetic variations
including point substitutions, copy number alterations, insertions and
deletions. At present, a few genetic variation repositories for some
individual NDDs have been created, however, these databases are needed
to be integrated and expanded to all the NDDs for systems biological
investigation. We here build a relational database termed as NDDVD to
integrate all the variations of NDDs using Leiden Open Variation
Database (LOVD) platform. The items in the NDDVD are collected manually
from PubMed or extracted from the existed variation databases. The
cross-disease database includes over 6374 genetic variations of 289
... (More)Neurodegenerative diseases (NDDs) are associated with genetic variations
(Less)
including point substitutions, copy number alterations, insertions and
deletions. At present, a few genetic variation repositories for some
individual NDDs have been created, however, these databases are needed
to be integrated and expanded to all the NDDs for systems biological
investigation. We here build a relational database termed as NDDVD to
integrate all the variations of NDDs using Leiden Open Variation
Database (LOVD) platform. The items in the NDDVD are collected manually
from PubMed or extracted from the existed variation databases. The
cross-disease database includes over 6374 genetic variations of 289
genes associated with 37 different NDDs. The patterns, conservations and
biological functions for variations in different NDDs are statistically
compared and a user-friendly interface is provided for NDDVD at: http://bioinf.suda.edu.cn/NDDvarbase/LOVDv.3.0.
- author
- Yang, Yang LU ; Xu, Chen ; Liu, Xingyun ; Xu, Chao ; Zhang, Yuanyuan ; Shen, Li ; Vihinen, Mauno LU and Shen, Bairong
- organization
- publishing date
- 2018-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Database: the journal of biological databases and curation
- volume
- 2018
- article number
- bay018
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85054772621
- pmid:29688368
- ISSN
- 1758-0463
- DOI
- 10.1093/database/bay018
- language
- English
- LU publication?
- yes
- id
- f3cadaaa-9a01-42c2-b059-d774a6bfd51d
- date added to LUP
- 2018-11-13 12:30:01
- date last changed
- 2024-08-20 03:40:23
@article{f3cadaaa-9a01-42c2-b059-d774a6bfd51d, abstract = {{<p>Neurodegenerative diseases (NDDs) are associated with genetic variations<br> including point substitutions, copy number alterations, insertions and <br> deletions. At present, a few genetic variation repositories for some <br> individual NDDs have been created, however, these databases are needed <br> to be integrated and expanded to all the NDDs for systems biological <br> investigation. We here build a relational database termed as NDDVD to <br> integrate all the variations of NDDs using Leiden Open Variation <br> Database (LOVD) platform. The items in the NDDVD are collected manually <br> from PubMed or extracted from the existed variation databases. The <br> cross-disease database includes over 6374 genetic variations of 289 <br> genes associated with 37 different NDDs. The patterns, conservations and<br> biological functions for variations in different NDDs are statistically<br> compared and a user-friendly interface is provided for NDDVD at: http://bioinf.suda.edu.cn/NDDvarbase/LOVDv.3.0.</p>}}, author = {{Yang, Yang and Xu, Chen and Liu, Xingyun and Xu, Chao and Zhang, Yuanyuan and Shen, Li and Vihinen, Mauno and Shen, Bairong}}, issn = {{1758-0463}}, language = {{eng}}, month = {{01}}, publisher = {{Oxford University Press}}, series = {{Database: the journal of biological databases and curation}}, title = {{NDDVD : an integrated and manually curated Neurodegenerative Diseases Variation Database}}, url = {{http://dx.doi.org/10.1093/database/bay018}}, doi = {{10.1093/database/bay018}}, volume = {{2018}}, year = {{2018}}, }